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Sequential bilateral transplantation in Parkinson's disease: effects of the second graft.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Hagell, Peter Schrag, Anette Piccini, Paola Jahanshahi, Marjan Brown, Rachel Rehncrona, Stig Widner, Håkan Brundin, Patrik Rothwell, John C. Odin, P. Wenning, Gregor Karl Morrish, Paul K. Gustavii, Björn Björklund, Anders Brooks, David J. Marsden, C. David Quinn, Niall Lindvall, Olle |
| Copyright Year | 1999 |
| Abstract | Five parkinsonian patients who had received implants of human embryonic mesencephalic tissue unilaterally in the striatum 10-56 months earlier were grafted with tissue from four to eight donors into the putamen (four patients) or the putamen plus the caudate nucleus (one patient) on the other side, and were followed for 18-24 months. After 12-18 months, PET showed a mean 85% increase in 6-L-[18F]fluorodopa uptake in the putamen with the second graft, whereas there was no significant further change in the previously transplanted putamen. Two patients exhibited marked additional improvements after their second graft: 'on-off' fluctuations virtually disappeared, movement speed increased, and L-dopa could be withdrawn in one patient and reduced by 70% in the other. The improvement in one patient was moderate. Two patients with atypical features, who responded poorly to the first graft, worsened following the second transplantation. These findings indicate that sequential transplantation in patients does not compromise the survival and function of either the first or the second graft. Moreover, putamen grafts that restore fluorodopa uptake to normal levels can give improvements of major therapeutic value. |
| Starting Page | 564 |
| Ending Page | 569 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://brain.oxfordjournals.org/content/brain/122/6/1121.full.pdf |
| Alternate Webpage(s) | https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/brain/122/6/10.1093/brain/122.6.1121/2/1221121.pdf?Expires=1495952408&Key-Pair-Id=APKAIUCZBIA4LVPAVW3Q&Signature=F4vf6RfzPnZpTfxn9HI-r8RdWS0Vk9ibO7RTqIUgEgDd3dR83AByTV8NuS89TpH-hacAXAA--V9oWygFUaIoEUTjoFnyOzWPoe1AarPnVpZKn44TUfLCzi2XPYYerZAkstoRArf8O6z3Yxq3Ls0IvyR5iD-gkrcmAEfccOP4J-OBIQ-J7kmkkTxRvjfJGv-diiBdQY3nb4VKkCKaB-3IJgM3CIVH5DRqG7G2DdVecZDo8YBn86sdG657pLCY3k1FLHfLMSLRjgnfjN5pLNL6Lb74fVZVcZOIPtvJ~B4i9Ux~BvpOSv7fT-Bnj-6oVb-u2WCJxP4UPmKj6PdeGRdDuA__ |
| Alternate Webpage(s) | http://www.med.lu.se/content/download/35440/241843/file/Hagell%20et%20al%20Brain%201999.pdf |
| PubMed reference number | 10356064v1 |
| Volume Number | 122 |
| Part | 6 |
| Journal | Brain : a journal of neurology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Caudate nucleus structure Cell Nucleus Dopa Levodopa Midbrain structure Neostriatum Parkinson Disease Parkinsonian Disorders Patients Positron-Emission Tomography Structure of putamen Transplanted tissue fluorodopa F 18 |
| Content Type | Text |
| Resource Type | Article |
