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The DD genotype of the angiotensin-converting enzyme gene occurs in very low frequency in Australian Aboriginals.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Lester, Susan Heatley, Sue Bahnisch, J. Bannister, Kym Faull, Randall James Clarkson, Anthony |
| Copyright Year | 1999 |
| Abstract | BACKGROUND The DD genotype of the angiotensin-converting enzyme (ACE) gene appears to be an independent risk factor for myocardial infarction, left ventricular hypertrophy and an increased incidence and rate of progression of renal disease. The high incidence of renal disease and end-stage renal failure in the Australian Aboriginal population has prompted investigation of ACE genotypes in these people. METHODS ACE genotypes were determined in four groups: (i) normal Australian Caucasian blood donors (n = 100), (ii) Caucasian renal transplant recipients (n = 173), (iii) normal Australian Aboriginals from a single tribe (n = 184), and (iv) Australian Aboriginals included in the renal-transplant programme (n = 94). FINDINGS The D allele frequency in the normal Australian Caucasian (54.5%) and renal transplant groups (57.2%) was similar. However, the D allele frequency in the normal Australian Aboriginal (3%) and Aboriginal renal patient group (14.4%) was significantly lower than both Caucasian groups. INTERPRETATION The D allele of the ACE gene has little or no influence on the renal disease of Australian Aboriginals. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/ndt/14/4/10.1093_ndt_14.4.887/1/140887.pdf?Expires=1496183109&Key-Pair-Id=APKAIUCZBIA4LVPAVW3Q&Signature=AkGqIkIiPfa06jRG55wZ8OVfURImiDZXhPHlnulCWrp4EfpIWWoLcuI4Yc2WGhRs1gcJh5A8tUM~OWeKM7MTnztjxUsDl3tDpFSSfZq276vjMtPaSi6x4KKPQ5tqpk2vdT~xWHXI~p8RiSAa98KX819~f9o1A7~50DQ2ZNp-YIN4Wc0K4DUBqQZbNhQnAfCxqFpq2W90u0Nbb4hFsqH6JIo17eVLhfc49ntdiiI6UL7nMs8rGp4EBEnFmXUx31MEszoTFHrGPeagYfATxsU6PBxqTuVeY0LQQaMhlpcJbtG7SKuDrV6R2N9TxhPT1exnVdkfFk28RY6B6WEqxvmqDQ__ |
| PubMed reference number | 10328464v1 |
| Volume Number | 14 |
| Issue Number | 4 |
| Journal | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Angiotensin-Converting Enzyme Inhibitors Angiotensins Gene Frequency Genotype Hematological Disease Kidney Diseases Kidney Failure, Chronic Kidney Transplantation Myocardial Infarction Patients Peptidyl-Dipeptidase A Renal Insufficiency Transplant Recipients Ventricular hypertrophy |
| Content Type | Text |
| Resource Type | Article |
