NDLI: Is ACE gene polymorphism associated with lone atrial fibrillation?

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Is ACE gene polymorphism associated with lone atrial fibrillation?

Content Provider	Semantic Scholar
Author	Yamashita, Tsutomu Hayami, Noriyuki Ajiki, Kohsuke Oikawa, Nobuhiro Sezaki, Koichiro Inoue, Masaru Omata, Masao Murakawa, Yuji
Copyright Year	1997
Abstract	ACE (angiotensin converting enzyme) gene genotypes have been shown to be a risk factor for development of left ventricular hypertrophy and cardiomyopathy, upon the assumption that the DD genotype is linked to higher cellular ACE activity leading to myocardial fibrosis. To test an analogous hypothesis that the DD genotype favors myocardial fibrosis in the atrium and thus promotes atrial fibrillation without any structural heart diseases, we determined the distribution of the ACE gene genotypes in 77 patients with lone atrial fibrillation and investigated the effects of the ACE genotypes on the clinical characteristics of atrial fibrillation. The distribution of ACE genotypes was not significantly different between the patients and healthy volunteers. Also, the ACE gene genotypes did not affect the types of atrial fibrillation and the age at the onset of atrial fibrillation. Thus, these results refuted the hypothesis of possible relationships between ACE genotypes and lone atrial fibrillation through myocardial fibrosis, and indicated some unknown differences between the atrium and ventricle.
Starting Page	1
Ending Page	5
Page Count	5
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://www.jstage.jst.go.jp/article/ihj1960/38/5/38_5_637/_pdf/-char/en
PubMed reference number	9462412v1
Volume Number	38
Issue Number	5
Journal	Japanese heart journal
Language	English
Access Restriction	Open
Subject Keyword	Angiotensin-Converting Enzyme Inhibitors Angiotensins Atrial Fibrillation Cardiomyopathies Genotype Heart Atrium Heart Diseases Heart Ventricle Myocardial fibrosis Patients Peptidyl-Dipeptidase A Ventricular hypertrophy
Content Type	Text
Resource Type	Article

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