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IL-33, a Potent Inducer of Adaptive Immunity to Intestinal Nematodes
| Content Provider | Scilit |
|---|---|
| Author | Humphreys, Neil E. Xu, Damo Hepworth, Matthew R. Liew, Foo Y. Grencis, Richard K. |
| Copyright Year | 2008 |
| Description | IL-33 (IL-1F11) binds ST2 (IL-1R4), both of which are associated with optimal $CD4^{+}$ Th2 polarization. Exogenous IL-33 drives induction of Th2-associated cytokines and associated pathological changes within the gut mucosa. Th2 polarization is also a prerequisite to expulsion of the intestinal-dwelling nematode Trichuris muris. In this study, we demonstrate that IL-33 mRNA is expressed early during parasite infection and susceptible mice can be induced to expel the parasite by a regime of exogenous IL-33 administration. IL-33 prevents an inappropriate parasite-specific Th1-polarized response and induces IL-4, IL-9, and IL-13. This redirection requires the presence of T cells and must occur at the initiation of the response to the pathogen. Interestingly, exogenous IL-33 also induced thymic stromal lymphopoietin mRNA within the infected caecum, an epithelial cell-restricted cytokine essential for the generation of Th2-driven parasite immunity. IL-33 also acts independently of T cells, altering intestinal pathology in chronically infected SCID mice, leading to an increased crypt length and intestinal epithelial cell proliferation, but reducing goblet cell hyperplasia. Thus, the ability of IL-33 to induce Th2 responses has functional relevance in the context of intestinal helminth infection, particularly during the initiation of the response. |
| Ending Page | 2449 |
| Page Count | 7 |
| Starting Page | 2443 |
| ISSN | 00221767 |
| e-ISSN | 15506606 |
| DOI | 10.4049/jimmunol.180.4.2443 |
| Journal | The Journal of Immunology |
| Issue Number | 4 |
| Volume Number | 180 |
| Language | English |
| Publisher | The American Association of Immunologists |
| Publisher Date | 2008-02-15 |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
