Loading...
Please wait, while we are loading the content...
Similar Documents
Role of glia in neuropathic pain.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Liu, Fangting |
| Copyright Year | 2014 |
| Abstract | Neuropathic pain is experienced as a result of disease or physical injury affecting the somatosensory system. It can be associated with abnormal sensations (dysesthesia) or evoked by normally nonpainful stimuli. Glia has emerged as key regulators of neuropathic pain perception and potential targets for drug development. Glia are activated upon peripheral nerve damage and secrete a number of proinflammatory factors. This process involves many mechanisms including neuroinflammation, ion channel activation, and ligand-receptor interactions. This review describes recent advances in the understanding of neuropathic pain, including the role of glia and their targeting by current treatment approaches. |
| Starting Page | 798 |
| Ending Page | 807 |
| Page Count | 10 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.bioscience.org/fbs/getfile.php?FileName=/2014/v19/af/4247/4247.pdf |
| PubMed reference number | 24389224v1 |
| Volume Number | 19 |
| Journal | Frontiers in bioscience |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Abnormal sensation Cell secretion Dysesthesia Esthesia Ion Channel Ions Ligands Neuralgia Neurogenic Inflammation Neuroglia Pain Perception Peripheral Nerves Peripheral Neuropathy cellular targeting drug development nerve injury |
| Content Type | Text |
| Resource Type | Article |