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[Roles of transient receptor potential melastatin 2 expressed on immune cells in neuropathic pain].
| Content Provider | Semantic Scholar |
|---|---|
| Author | Nakagawa, Takayuki Isami, Koichi Haraguchi, Kayo So, Kanako Asakura, Kayoko Shirakawa, Hisashi Kaneko, Shuji |
| Copyright Year | 2014 |
| Abstract | Neuropathic pain is a pathological pain condition that often results from peripheral nerve injury. Several lines of evidence suggest that neuroinflammation mediated by the interaction between immune cells and neurons plays an important role in the pathogenesis of neuropathic pain. Transient receptor potential melastatin 2 (TRPM2) is a nonselective Ca(2+)-permeable cation channel that acts as a sensor for reactive oxygen species. Recent evidence suggests that TRPM2 expressed on immune cells plays an important role in immune and inflammatory responses. In this study, we examined the roles of TRPM2 expressed on immune and glial cells in neuropathic pain. TRPM2 deficiency attenuated pain behaviors (mechanical allodynia, thermal hyperalgesia and spontaneous pain behaviors) in various kinds of inflammatory and neuropathic pain, but not in nociceptive pain models. In peripheral nerve injury-induced neuropathic pain models, TRPM2 deficiency diminished infiltration of neutrophils mediated through CXCL2 production from macrophages around the injured peripheral nerve and activation of spinal microglia, suggesting that TRPM2 expressed on macrophages and microglia aggravates peripheral and spinal pronociceptive inflammatory responses. Furthermore, we examined the infiltration of peripheral immune cells into the injured nerve and spinal cord using bone marrow chimeric mice by crossing wildtype and TRPM2-knockout mice. The results suggest that TRPM2 plays an important role in the infiltration of peripheral immune cells, particularly macrophages, into the spinal cord, rather than into the injured nerves. The spinal infiltration of macrophages mediated by TRPM2 may contribute to the pathogenesis of neuropathic pain. |
| Starting Page | 250 |
| Ending Page | 250 |
| Page Count | 1 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://repository.kulib.kyoto-u.ac.jp/dspace/bitstream/2433/196044/1/yakushi.13-00236-2.pdf |
| PubMed reference number | 24584019v1 |
| Volume Number | 134 |
| Issue Number | 3 |
| Journal | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Behavior Bone Marrow Calcium Cations Hyperalgesia Microglia Neuralgia Neurogenic Inflammation Neuroglia Nociceptive Pain Peripheral Nerve Injuries Peripheral Nerves Reactive Oxygen Species Spinal Cord TRPM3 protein, human Wild Type inflammatory response nerve injury |
| Content Type | Text |
| Resource Type | Article |
