NDLI: Peripheral and central mechanisms of pain generation.

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Peripheral and central mechanisms of pain generation.

Content Provider	Semantic Scholar
Author	Schaible, H. G.
Copyright Year	2007
Abstract	Pain research has uncovered important neuronal mechanisms that underlie clinically relevant pain states such as inflammatory and neuropathic pain. Importantly, both the peripheral and the central nociceptive system contribute significantly to the generation of pain upon inflammation and nerve injury. Peripheral nociceptors are sensitized during inflammation, and peripheral nerve fibres develop ectopic discharges upon nerve injury or disease. As a consequence a complex neuronal response is evoked in the spinal cord where neurons become hyperexcitable, and a new balance is set between excitation and inhibition. The spinal processes are significantly influenced by brain stem circuits that inhibit or facilitate spinal nociceptive processing. Numerous mechanisms are involved in peripheral and central nociceptive processes including rapid functional changes of signalling and long-term regulatory changes such as up-regulation of mediator/receptor systems. Conscious pain is generated by thalamocortical networks that produce both sensory discriminative and affective components of the pain response.
Starting Page	3
Ending Page	28
Page Count	26
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://www.springer.com/cda/content/document/cda_downloaddocument/9783540338222-c1.pdf?SGWID=0-0-45-334392-p173664915
Alternate Webpage(s)	http://www.springer.com/cda/content/document/cda_downloaddocument/9783540338222-c1.pdf?SGWID=0-0-45-334392-p173664915
PubMed reference number	17087118v1
Volume Number	177
Journal	Handbook of experimental pharmacology
Language	English
Access Restriction	Open
Subject Keyword	Body Fluid Discharge Brain Stem Ectopic Graft Excitation Inflammation Mediator brand of benfluorex hydrochloride Neuralgia Nociceptors Pain Peripheral Nerves Peripheral Neuropathy Spinal Cord Up-Regulation (Physiology) biological signaling nerve injury
Content Type	Text
Resource Type	Article

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