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Serum Soluble Interleukin‐2 Receptor Levels in Patients with Adult T‐cell Leukemia and Human T‐cell Leukemia/Lymphoma Virus Type‐I Seropositive Healthy Carriers
| Content Provider | Semantic Scholar |
|---|---|
| Author | Motoi, Tomomi Uchiyama, Takashi Uchino, Haruto Ueda, Ryuzo Araki, Kenji |
| Copyright Year | 1988 |
| Abstract | Using an enzyme-linked immunosorbent assay (ELISA) technique, we measured the soluble interleukin 2 receptor (s-IL-2R) levels in the sera of patients with adult T-cell leukemia (ATL) in Japan. The s-IL-2R levels in the sera of the ATL patients were markedly higher (range 540-310, 400 U/ml, mean +/- SD = 62,800 +/- 81,000 U/ml, n = 42) than those in normal individuals (range 42-950 U/ml, mean +/- SD = 322 +/- 198 U/ml, n = 35, P less than 0.01). The patients with acute-type or lymphoma-type ATL had high s-IL-2R levels (range 11,900-310,400 U/ml, mean +/- SD = 110,340 +/- 370 U/ml, n = 15; range 26,400-214,400 U/ml, mean +/- SD = 90,170 +/- 59,040 U/ml, n = 7, respectively). All of the patients with hypercalcemia (Ca greater than 10 mg/dl) or elevated serum LDH levels (LDH greater than 500 IU/liter) also had s-IL-2R levels above 10,000 U/ml. The high s-IL-2R levels in the sera of ATL patients indicate abnormal IL-2 receptor production and its release from the leukemic cells in vivo. Thus, the serum s-IL-2R level may be a sensitive and useful marker to monitor the total amount of tumor cells in ATL, especially in the lymphoma type. We next examined the serum s-IL-2R levels in human T-cell leukemia/lymphoma virus type-I (HTLV-I) seropositive healthy carriers to investigate whether there might be abnormal IL-2 receptor expression in such individuals. However, there was no statistically significant difference between the s-IL-2R level of 71 HTLV-I seropositive healthy carriers (range 65-880 U/ml, mean +/- SD = 394 +/- 212 U/ml) and that of 71 age- and sex-matched normal individuals (range 33-950 U/ml, mean +/- SD = 357 +/- 224 U/ml) who lived in Okinawa Prefecture. |
| Starting Page | 593 |
| Ending Page | 599 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 2900231v1 |
| Volume Number | 79 |
| Journal | Japanese journal of cancer research : Gann |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Adult T-Cell Lymphoma/Leukemia Cellular Phone Enzyme-Linked Immunosorbent Assay Ethanol 0.62 ML/ML Topical Gel Hypercalcemia Leukemia, B-Cell Leukemia, T-Cell Lymphoma Neoplasms Patients Physiological Sexual Disorders Recombinant Interleukins T-Lymphocyte leukemia liter mg/dl receptor |
| Content Type | Text |
| Resource Type | Article |
