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Influence of filgrastim (granulocyte colony-stimulating factor) on human immunodeficiency virus type 1 RNA in patients with cytomegalovirus retinitis.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Davidson, Michael Min, Yuan-I Holbrook, Janet T. Quinn, Thomas C. Murphy, Robert |
| Copyright Year | 2002 |
| Abstract | Filgrastim, or granulocyte colony-stimulating factor, reverses neutropenia associated with human immunodeficiency virus type 1 (HIV-1) and cytomegalovirus (CMV) infections. During a trial of anti-CMV retinitis therapies coadministered with antiretroviral therapy, 2-4 plasma specimens of HIV-1 RNA were collected from 36 HIV-1-infected patients receiving filgrastim to prevent neutropenia and from 36 patients not receiving filgrastim. For both groups, the crude mean and mean rate of change of HIV-1 log(10) RNA levels were similar. Adjustment for covariates (CD4(+) T cell lymphocytes, virus load at enrollment, level of neutropenia and antiretroviral therapy [mainly non-highly active antiretroviral therapy], and anti-CMV therapy during follow-up) resulted in a mean log(10) HIV-1 RNA level for individuals receiving filgrastim versus those not receiving the drug of 5.11 versus 4.87 (P=.12) and respective log mean rates of change per month of -0.08 versus -0.21 (P=.08). This latter difference has borderline statistical significance, which suggests that filgrastim may reduce the decline of HIV-1 RNA loads. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/jid/186/7/10.1086/342956/2/186-7-1013.pdf?Expires=1492579393&Key-Pair-Id=APKAIUCZBIA4LVPAVW3Q&Signature=fDAkVhVx-BWpXK3Ng11AZdPBDKdYycB2XvPunIOg-vAG5-w4CE9AiZHlF25uRAT0xbhX9-OT6ejyc2YywWyIIVm5OUNuLt2HOmF9KMZXxUdav3mnqhUMnnjr6wMEJxLfjPqTeuiyhdN3VeS2oaJvLP48SXXzTOLu~zQbwb4~zO-Bblkv4KPvP3Fc5DeCsWFDcX4TglthX27sIpNB3tn8KanJZ0yXDd-1ypLDAChgi0V7EZrNl-23QtOhUnYNeEk1FO1xjN7ZkUcURqB0I4eRlBctOMwiibA19Qxk2DStWKO0faqC5m6gtmTd~W9FB30NFllGBGR4i~4~ngojkCMp-Q__ |
| PubMed reference number | 12232843v1 |
| Volume Number | 186 |
| Issue Number | 7 |
| Journal | The Journal of infectious diseases |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Antiretroviral Therapy, Highly Active Antiretroviral therapy CSF3 gene Colony-Stimulating Factors Cytomegalovirus Infections Cytomegalovirus Retinitis Filgrastim HIV Infections HIV-1 Immunologic Deficiency Syndromes Infection Neutropenia P-Value Patients RNA Specimen Stimulation (motivation) Therapeutic procedure Viral load measurement granulocyte |
| Content Type | Text |
| Resource Type | Article |
