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Long-lasting remission of cytomegalovirus retinitis without maintenance therapy in human immunodeficiency virus-infected patients.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Tural, Cristina Romeu, Joan Sirera, Guillem Andreu, David Conejero, Mia Judith U. Ruíz, Sara Alvarez Jou, Antoni Bonjoch, Anna Ruiz, Lidia Arnó, Albert Clotet, Bonaventura |
| Copyright Year | 1998 |
| Abstract | Seven AIDS patients who were receiving suppressive therapy for previously diagnosed cytomegalovirus (CMV) retinitis were offered treatment with protease inhibitors (PIs). Secondary prophylaxis for CMV was discontinued after 3 months of therapy with PIs if patients had >150 CD4 cells/mm3 and a human immunodeficiency virus (HIV) load of <200 copies/mL and if they were negative for CMV as determined by qualitative CMV polymerase chain reaction (PCR). Ophthalmologic exams were done periodically. After a median follow-up of 9 months (range, 9-12), no new episodes of CMV retinitis were observed. CD4 cell counts were >150 cells/mm3 in all cases, HIV loads were <200 copies/mL, and results for qualitative CMV PCRs remained negative. These observations suggest that for selected patients with healed CMV retinitis who have immunologic and virologic evidence of a clinical response to potent combination antiretroviral therapy, temporary discontinuation of a chronic anti-CMV suppressive therapy may not result in further retinal necrosis. However, the long-term immunologic benefit of PIs and hence the safety of prolonged withdrawal of anti-CMV therapy is unknown. |
| Starting Page | 46 |
| Ending Page | 53 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/jid/177/4/10.1086/517399/2/177-4-1080.pdf?Expires=1492417412&Key-Pair-Id=APKAIUCZBIA4LVPAVW3Q&Signature=I8i9hVwSG~zpvGJMPPccM4ahK5yQEnspjVslvviSWf45rN2B~gD99LKF9JYWeP57knMkChcSvmPTwKJ5YWmiiQxzzgFM9HoJe~i57wfl-etSoP5Q9a425bEppdHGTm1O~s59h~8QYpkPtITGhMHUHimFML0m981Rsf1xlW7P0rVh36IWYSOeSpu2itaMUTqqpfU96eS5bG3uV668TfyoO7UG4UL8-K29l~EpC70Osbw-aYmAZ43tFJ6TlJpeFZ30zU9hln1ZBaQ5NUNXOVJWD2VZ8Wsyz4cIUdz6kWzwF1iD0OCMhhv83utpcXQM9PlLFIQqOvZ2qy5ijYXcejwpCA__ |
| PubMed reference number | 9534987v1 |
| Volume Number | 177 |
| Issue Number | 4 |
| Journal | The Journal of infectious diseases |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Acquired Immunodeficiency Syndrome Antiretroviral therapy Cell Count Copy (object) Cubic Millimeter Cytomegalovirus Infections Cytomegalovirus Retinitis Endopeptidases Follow-Up Report HIV Infections Immunologic Deficiency Syndromes Kidney Papillary Necrosis Patients Polymerase Chain Reaction Protease Inhibitors Retina |
| Content Type | Text |
| Resource Type | Article |
