NDLI: C-reactive protein/albumin ratio as prognostic score in oral squamous cell carcinoma

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C-reactive protein/albumin ratio as prognostic score in oral squamous cell carcinoma

Content Provider	Semantic Scholar
Author	Park, Heung-Chul Kim, Moon Young Kim, Chul-Hwan
Copyright Year	2016
Abstract	OBJECTIVES Many studies have examined histopathological factors and various prognostic scores related to inflammation to predict outcomes. Here, we examined the prognostic value of the C-reactive protein/albumin (CRP/alb) ratio in oral squamous cell carcinoma (OSCC). MATERIALS AND METHODS This retrospective study included 40 patients with OSCC. Using univariate and multivariate analyses, we focused on the correlation of the CRP/alb ratio with clinicopathological characteristics and with overall survival. We then compared five inflammation-based prognostic scores, CRP/alb ratio, modified Glasgow Prognostic Score (mGPS), neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and prognostic nutritional index (PNI), based on receiver operating characteristic (ROC) curves. RESULTS The optimal cut-off value for the CRP/alb ratio was 0.085. The group with a high CRP/alb ratio had a high TNM clinical stage (P=0.002) and larger primary tumors (P=0.029), with statistically significant differences in lymph node metastasis and distant metastasis. In addition, when the CRP/alb ratio was high, multivariate analysis showed a lower survival rate (P=0.002; hazard ratio=6.078), and the ROC curve showed more outstanding discriminatory ability regarding overall survival compared to other inflammation-based prognostic scores. CONCLUSION The CRP/alb ratio can be an independent prognostic factor when predicting prognosis in OSCC and has good prognostic ability.
Starting Page	243
Ending Page	250
Page Count	8
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://synapse.koreamed.org/Synapse/Data/PDFData/3070JKAOMS/jkaoms-42-243.pdf
PubMed reference number	5104865
Volume Number	42
Journal	Journal of the Korean Association of Oral and Maxillofacial Surgeons
Language	English
Access Restriction	Open
Subject Keyword	Anatomic Node C-reactive protein C-reactive protein measurement Chitinophaga terrae Distant Metastasis Forecast of outcome Large Lymphocyte Count measurement Neoplasms Nutrition Indexes Overall Survival Patients Platelet Count measurement Prognostic Factors Prognostic Nutritional Index (PNI) Receiver Operating Characteristic Receiver Operator Characteristics Squamous Epithelial Cells Squamous cell carcinoma chang-chul-eui-ee-in-tang lymph node metastases lymph nodes neutrophil primary tumor
Content Type	Text
Resource Type	Article

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