The prognostic value of lymph node ratio in comparison to positive lymph node count in penile squamous cell carcinoma.

Content Provider	Europe PMC
Author	Yu, Jiajie Long, Qian Zhang, Zhiqiang Liao, Shufen Zheng, Fufu
Abstract	PurposePenile cancer is a rare male neoplasm with a wide variation in its global incidence. In this study, the prognostic value of lymph node ratio (LNR) was compared to that of positive lymph node count (PLNC) in penile squamous cell carcinoma.MethodsA total of 249 patients with penile squamous cell carcinoma were enrolled from The Surveillance, Epidemiology, and End Results (SEER) database between 2010 and 2015. The X-tile program was used to calculate the optimal cut-off values of LNR and PLNC that discriminate survival. We used the χ2 or the Fisher exact probability test to assess the association between clinical-pathological characteristics and LNR or PLNC. Univariate and multivariate Cox regression analyses were performed to identify independent prognostic factors for survival. Spearman correlation analysis was used to determine the correlation between LNR and PLNC.ResultsWe found that patients with high LNR tended to have advanced N stage, the 7th AJCC stage, and higher pathological grade, while patients with high PLNC had advanced N stage and the 7th AJCC stage. Univariate Cox regression analysis revealed that the N stage, M stage, the 7th AJCC stage, lymph-vascular invasion, LNR, and PLNC were significantly associated with prognosis. Multivariate Cox regression analysis demonstrated that LNR rather than PLNC was an independent prognostic factor for cancer-specific survival. Subgroup analysis of node-positive patients showed that LNR was associated with CSS, while PLNC was not.ConclusionLNR was a better predictor for long-term prognosis than PLNC in patients with penile squamous cell carcinoma.
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ISSN	03011623
Journal	International Urology and Nephrology [Int Urol Nephrol]
Volume Number	53
DOI	10.1007/s11255-021-02996-3
PubMed Central reference number	PMC8599252
Issue Number	12
PubMed reference number	34585313
e-ISSN	15732584
Language	English
Publisher	Springer Netherlands
Publisher Date	2021-09-28
Publisher Place	Dordrecht
Access Restriction	Open
Rights License	Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2021
Subject Keyword	Lymph node ratio Positive lymph node count Penile squamous cell carcinoma SEER
Content Type	Text
Resource Type	Article
Subject	Urology Nephrology