NDLI: Platelet tests and antiplatelet drugs in coronary artery disease.

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Platelet tests and antiplatelet drugs in coronary artery disease.

Content Provider	Semantic Scholar
Author	Boer, A. S. De Han, Ping Turpie, Alexander G. G. Butt, R. W. Gent, M. Genton, Edward
Copyright Year	1983
Abstract	This study was designed to clarify discrepancies in the literature concerning platelet survival time and beta-thromboglobulin (beta TG) levels in patients with coronary artery disease (CAD) and the effect of platelet-suppressant drugs on these tests. Platelet survival time and plasma beta TG levels were determined in 48 patients with angiographically documented CAD. The effect of sulfinpyrazone or aspirin/dipyridamole on these measurements was investigated in a double-blind, crossover trial that included a placebo phase. In patients with CAD, the mean plasma beta TG concentration was significantly elevated, but the mean platelet survival time was not significantly different from that in controls. Treatment with sulfinpyrazone or aspirin/dipyridamole did not produce changes in platelet survival time or plasma beta TG concentration that were significantly different from the values during the placebo phase. This study demonstrates that compared with the spontaneous variation in platelet survival time or beta TG concentration, there was no measureable effect of sulfinpyrazone or aspirin/dipyridamole on the results of the tests.
Starting Page	35
Ending Page	46
Page Count	12
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://circ.ahajournals.org/content/circulationaha/67/3/500.full.pdf
Alternate Webpage(s)	http://circ.ahajournals.org/content/circulationaha/67/3/500.full.pdf?download=true
PubMed reference number	6217921v1
Volume Number	67
Issue Number	3
Journal	Circulation
Language	English
Access Restriction	Open
Subject Keyword	Antiplatelet Agents Arteriopathic disease Aspirin / Dipyridamole Blood Platelet Disorders Blood Platelets Coronary Artery Disease Cross-Over Studies Document completion status - Documented Kidney Diseases PPBP gene Patients Recombinant Beta Thromboglobulin Sulfinpyrazone beta Thalassemia
Content Type	Text
Resource Type	Article

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