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Whole blood platelet function in acute ischemic stroke. Importance of dense body secretion and effects of antithrombotic agents.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Joseph, Rajiv D'andrea, Gabriele Oster, Solveig Welch, Kenneth Michael A. |
| Copyright Year | 1989 |
| Abstract | We studied platelet function in whole blood, a situation that better reflects the in vivo state, from 85 patients with acute ischemic stroke and from 19 healthy controls. Patients receiving no antithrombotic drugs demonstrated increased platelet dense body secretion without an associated increase in platelet aggregation, thus raising the possibility that dense body secretion may be of separate importance in cerebral infarction. Our results also suggest that dense body secretion may occur independently of aggregation. Heparin and heparin plus warfarin were ineffective in reducing the high level of dense body secretion seen in acute cerebral infarction, whereas treatment with aspirin plus dipyridamole inhibited both dense body secretion and platelet aggregation. It seems worthwhile to investigate the usefulness of antiplatelet drugs in the treatment of acute ischemic stroke wherein clinical outcome is correlated with the extent of suppression of platelet dense body secretion. |
| Starting Page | 38 |
| Ending Page | 44 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://stroke.ahajournals.org/content/strokeaha/20/1/38.full.pdf |
| Alternate Webpage(s) | http://stroke.ahajournals.org/content/strokeaha/20/1/38.full.pdf?download=true |
| PubMed reference number | 2911833v1 |
| Volume Number | 20 |
| Issue Number | 1 |
| Journal | Stroke |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Antiplatelet Agents Aspirin Blood Platelet Disorders Blood Platelets Bodily secretions Body Dysmorphic Disorders Cerebral Infarction Dipyridamole Leukemia, Myelocytic, Acute Lewy Body Disease Patients Platelet dense granule Warfarin heparin |
| Content Type | Text |
| Resource Type | Article |
