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Studies of platelet factor 4 and beta thromboglobulin release during exercise: lack of relationship to myocardial ischemia.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Stratton, John R. Malpass, T. W. Ritchie, James L. Pfeifer, Michael A. Harker, Laurence A. |
| Copyright Year | 1982 |
| Abstract | SUMMARY Platelet activation, which results in release of the platelet-specific proteins platelet factor 4 (PF4) and BTG thromboglobulin (BTG), may participate in exercise-induced myocardial ischemia by the formation of intravascular platelet aggregates or the generation of vasoactive substances such as thrombox-ane A2. We sought to determine if platelet release occurs during exercise-induced ntyocardial ischemia and its relationship to exercise-induced catecholamine release in 10 normal males (mean age 29 + 6 years) and 25 males with proved coronary artery disease (mean age 60 ± 8 years) who performed maximal, symptom-limited treadmill exercise tests. None of the subjects took drugs known to modify platelet behavior; 17 coronary artery disease patients took B-blocking agents. Plasma and urine PF4, plasma BTG and plasma catecholamines were measured before and immediately after exercise. Plasma PF4 and BTG were also measured 30 minutes after exercise. Ischemia, defined as angina or 1 mm or more of horizontal or downsloping ST depression, developed in 14 coronary artery disease patients. In young normal subjects during exercise, plasma PF4 increased from 2.1 ± 1.2 at rest to 4.7 ± 2.6 ng/ml at maximal exercise (p < 0.01 rest vs exercise) and plasma BTG increased from 11.7 ± 5.4 to 16.7 ± 7.7 ng/ ml (p < 0.01 rest vs exercise). Among the 25 coronary artery disease patients, plasma PF4 during exercise increased slightly but significantly, from 2.1 1.4 at rest to 2.6 ± 2.2 ng/ml at exercise (p < 0.01); plasma BTG did not change significantly, from 13.3 6.0 at rest to 14.1 ± 5.8 ng/ml during exercise. The small exercise-induced elevations in plasma PF4 and BTG in all 25 coronary artery disease patients were significantly less than those in the 10 young normal subjects (both p < 0.01 vs normals). Among the subset of 14 coronary artery disease patients with exercise-induced ischemia, neither plasma PF4 nor BTG increased significantly (PF4 from 2.6 1.7 at rest to 3.0 ± 2.9 ng/ml with exercise; plasma BTG from 13.6 ± 6.4 to 14.1 ± 7.1 ng/ml). The 14 coronary artery disease patients with ischemia had less exercise-induced elevation in both plasma PF4 and BTG than normal subjects (both p < 0.05). Plasma PF4 and BTG levels 30 minutes after exercise were not significantly different from rest levels in any subject group. Mean rest, peak exercise, and 30-minute postexercise plasma PF4 and BTG values did not differ significantly between the 17 coronary disease patients … |
| Starting Page | 33 |
| Ending Page | 43 |
| Page Count | 11 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://circ.ahajournals.org/content/circulationaha/66/1/33.full.pdf?download=true |
| Alternate Webpage(s) | http://circ.ahajournals.org/content/circulationaha/66/1/33.full.pdf |
| PubMed reference number | 6177442v1 |
| Volume Number | 66 |
| Issue Number | 1 |
| Journal | Circulation |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Angina Pectoris Arteriopathic disease Blood Platelet Disorders Blood Platelets Catecholamines Coronary Artery Disease Coronary heart disease Depressive disorder Exercise stress test Hypoxia-Ischemia, Brain Microgram per Liter Myocardial Ischemia Patients Platelet Factor 4 SCL-70 extractable nuclear Ab:PrThr:Pt:Ser:Ord Subgroup beta-2'-deoxythioguanosine beta-Thromboglobulin beta-Thromboglobulin, human |
| Content Type | Text |
| Resource Type | Article |
