NDLI: Diagnosis of tuberculosis based on the two specific antigens ESAT-6 and CFP10.

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Diagnosis of tuberculosis based on the two specific antigens ESAT-6 and CFP10.

Content Provider	Semantic Scholar
Author	Pinxteren, Laurens Van Ravn, Pernille Agger, Else Marie Pollock, John Andersen, Peter Hvilshøj
Copyright Year	2000
Abstract	Tests based on tuberculin purified protein derivative (PPD) cannot distinguish between tuberculosis infection, Mycobacterium bovis BCG vaccination, or exposure to environmental mycobacteria. The present study investigated the diagnostic potential of two Mycobacterium tuberculosis-specific antigens (ESAT-6 and CFP10) in experimental animals as well as during natural infection in humans and cattle. Both antigens were frequently recognized in vivo and in vitro based on the induction of delayed-type hypersensitivity responses and the ability to induce gamma interferon production by lymphocytes, respectively. The combination of ESAT-6 and CFP10 was found to be highly sensitive and specific for both in vivo and in vitro diagnosis. In humans, the combination had a high sensitivity (73%) and a much higher specificity (93%) than PPD (7%).
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://cvi.asm.org/content/7/2/155.full.pdf
PubMed reference number	10702486v1
Volume Number	7
Issue Number	2
Journal	Clinical and diagnostic laboratory immunology
Language	English
Access Restriction	Open
Subject Keyword	Bacillus Calmette-Guerin Delayed Hypersensitivity Drug Allergy ELECTROSURGICAL DEVICE Genus Mycobacterium In Vitro [Publication Type] Latent Tuberculosis Mycobacterium bovis Mycobacterium tuberculosis Purified Protein Derivative of Tuberculin Recombinant Interferon-gamma
Content Type	Text
Resource Type	Article

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