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Comparison of follicle-stimulating-hormone-stimulated dimeric inhibin and estradiol responses as indicators of granulosa cell function in polycystic ovary syndrome and normal women.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Coffler, Mickey S. Malcom, Pamela J. Chang, Russell Jeffrey |
| Copyright Year | 2006 |
| Abstract | CONTEXT Follicular phase secretion of inhibin B, like that of estradiol (E(2)), correlates with the quantity and quality of developing follicles. However, it has not been established whether inhibin B responses to gonadotropin stimulation parallel those of E(2) as a reflection of granulosa cell functional capacity. OBJECTIVE Our objective was to determine whether inhibin B responses to FSH stimulation are similar to those of E(2) in women with polycystic ovary syndrome (PCOS) and normal women. DESIGN AND SETTING We conducted a prospective study to compare ovarian responses in two groups of women at a general clinical research center in a tertiary academic medical center. PATIENTS Women with PCOS, 18-35 yr (n = 19), and normal ovulatory controls, 18-35 yr (n = 7), were recruited for study. INTERVENTIONS Serum samples were measured over a 24-h period after an iv injection of recombinant human FSH, 150 IU. MAIN OUTCOME MEASURES Serum E(2), inhibin A, and inhibin B responses after FSH administration were assessed. RESULTS In PCOS women, the 24-h production of inhibin B and E(2) after FSH was significantly greater than that of normal controls. Within the PCOS group, the fold change in inhibin B was significantly greater than that of E(2). Inhibin A responses between groups were similar and of markedly lower magnitude. CONCLUSIONS FSH-stimulated inhibin B responses may be employed to assess the functional capacity of granulosa cells in PCOS and normal women. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://saegre.org.ar/biblioteca/arbol_bibliografico/noviembre2006/00004678-200608000-00021-fonadotrof.pdf |
| PubMed reference number | 16720653v1 |
| Volume Number | 91 |
| Issue Number | 8 |
| Journal | The Journal of clinical endocrinology and metabolism |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Academic Medical Centers Cell physiology Estradiol Gonadotropins Inhibin A Inhibin-beta Subunits Ovarian Follicle Patients Polycystic Ovary Syndrome Recombinants Sex Reassignment Procedures Stimulation (motivation) Urofollitropin granulosa cell inhibin B tertiary |
| Content Type | Text |
| Resource Type | Article |
