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MICA-129 genotype, soluble MICA, and anti-MICA antibodies as biomarkers of chronic graft-versus-host disease.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Boukouaci, Wahid Busson, Mervyn Latour, Régis Peffault De Rocha, V. Luis Fernando Suberbielle, Caroline Bengoufa, Djaouida Dulphy, Nicolas Haas, Philippe Scieux, Catherine Amroun, Habiba Gluckman, Eliane Krishnamoorthy, Rajagopal Toubert, Antoine Charron, Dominique J. Socié, Gérard Tamouza, Ryad |
| Copyright Year | 2009 |
| Abstract | The MHC class I-related chain A (MICA) molecules exist as membrane-bound and soluble isoforms and are encoded by a polymorphic gene. Their genetic and phenotype characteristics have been studied in various pathologic settings but not in the context of hematopoietic stem cell transplantation (HSCT). Here, we evaluated whether MICA-related features namely MICA-129 gene polymorphism, serum levels of soluble MICA (sMICA) and anti-MICA antibodies (MICA Abs) before and after HSCT could influence the incidence of chronic graft-versus-host disease (cGVHD) and relapse of their disease in 211 HLA-identical sibling pairs and in a subset of 116 recipients, respectively. Although the MICA-129 val/val genotype and elevated sMICA serum levels after HSCT are independently associated with the incidence of cGVHD (P = .002 and .001) regardless of history of acute GVHD, the presence of MICA Abs before transplantation confers protection against cGVHD (P = .04). There is an inverse relationship between MICA Abs and sMICA, suggesting an antibody-based neutralization of deleterious effects of sMICA. Similarly, these genetic and phenotype characteristics of MICA influence the incidence of relapse. Altogether, these data suggest that the studied MICA genotype and phenotype specificities could be used as relevant biomarkers for cGVHD monitoring. |
| Starting Page | 1469 |
| Ending Page | 1472 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.bloodjournal.org/content/bloodjournal/114/25/5216.full.pdf?sso-checked=true |
| PubMed reference number | 19786616v1 |
| Alternate Webpage(s) | https://doi.org/10.1182/blood-2009-04-217430 |
| DOI | 10.1182/blood-2009-04-217430 |
| Journal | Blood |
| Volume Number | 114 |
| Issue Number | 25 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Acute GVH disease Allogeneic Hematopoietic Stem Cell Transplantation Biological Markers Chronic Graft Versus Host Disease Graft versus host disease prophylaxis/therapy HIV Antibodies Hematopoietic stem cells Hemopoietic stem cell transplant Histocompatibility Antigens Class II Neutralization (Chemistry) Protein Isoforms Subgroup Tissue membrane Transplanted tissue Valine soluble NSF attachment protein |
| Content Type | Text |
| Resource Type | Article |
