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Transfer of allogeneic CD62L- memory T cells without graft-versus-host disease.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Cui, Xiuyu Sempowski, Gregory D. Liu, Congxiao Chao, Nelson J. |
| Copyright Year | 2004 |
| Abstract | The major challenge in allogeneic hematopoietic cell transplantation is how to transfer allogeneic T-cell immunity without causing graft-versus-host disease (GVHD). Here we report a novel strategy to selectively prevent GVHD by depleting CD62L(+) T cells (naive and a subset of memory T cells). In unprimed mice, CD62L(-) T cells (a subset of memory T cells) failed to proliferate in response to alloantigens (which the mice have never previously encountered) and were unable to induce GVHD in allogeneic hosts. CD62L(-) T cells contributed to T-cell reconstitution by peripheral expansion as well as by promoting T-cell regeneration from bone marrow stem/progenitor cells. CD62L(-) T cells from the animals previously primed with a tumor cell line (BCL1) were able to inhibit the tumor growth in vivo but were unable to induce GVHD in the third-party recipients. This novel technology may allow transfer of allogeneic recall antitumor and antimicrobial immunity without causing GVHD. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.bloodjournal.org/content/bloodjournal/early/2003/10/09/blood-2003-08-2987.full.pdf?sso-checked=true |
| PubMed reference number | 14551132v1 |
| Volume Number | 103 |
| Issue Number | 4 |
| Journal | Blood |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Bone Marrow Cell Line, Tumor Cell Transplantation Graft versus host disease prophylaxis/therapy Graft-vs-Host Disease Hemopoietic stem cell transplant Leukemia, B-Cell Neoplasms Promotion (action) Subgroup T-Lymphocyte Transplanted tissue |
| Content Type | Text |
| Resource Type | Article |
