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Distinct roles for donor- and host-derived antigen-presenting cells and costimulatory molecules in murine chronic graft-versus-host disease: requirements depend on target organ.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Anderson, Britt E. McNiff, Jennifer Madison Jain, D. Blazar, Bruce R. Shlomchik, Warren D. Shlomchik, Mark J. |
| Copyright Year | 2005 |
| Abstract | The application of allogeneic stem cell transplantation (alloSCT) is limited by graft-versus-host disease (GVHD). GVHD can be divided into acute and chronic forms that likely have different requirements for initiation and pathogenesis mechanisms. In prior studies we demonstrated that residual host antigen-presenting cells (APCs) were required to initiate acute GVHD (aGVHD) mediated by CD8 T cells. In contrast, here we demonstrate that either donor or host APCs can initiate CD4-mediated GVHD in a model that has features of chronic GVHD (cGVHD). Both donor and host APCs must provide CD80/86-dependent costimulation to elicit maximal cGVHD, and there is no GVHD when both donor and host lack CD80/86. Finally, we were surprised to find that, although either donor or host APCs are sufficient to stimulate skin cGVHD, donor APCs play a dominant role in intestinal cGVHD. Both CD40 and CD80/86 are critical for donor APC function in intestinal cGVHD, but only CD80/86 is required for skin cGVHD. Thus, there are target-tissue-specific differences in APC requirements. These results identify differences in APC requirements between CD8-mediated aGVHD and CD4-mediated cGVHD. They further highlight donor APCs as additional targets for GVHD therapy. |
| Starting Page | 1101 |
| Ending Page | 1104 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.bloodjournal.org/content/bloodjournal/105/5/2227.full.pdf?sso-checked=true |
| Alternate Webpage(s) | http://www.bloodjournal.org/content/bloodjournal/early/2004/11/02/blood-2004-08-3032.full.pdf?sso-checked=true |
| PubMed reference number | 15522961v1 |
| Volume Number | 105 |
| Issue Number | 5 |
| Journal | Blood |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Acute GVH disease Allogeneic Hematopoietic Stem Cell Transplantation Chronic Graft Versus Host Disease Graft versus host disease prophylaxis/therapy Graft-vs-Host Disease Leukemia, Myeloid, Chronic-Phase Stem cell transplant Stem cells Transplanted tissue |
| Content Type | Text |
| Resource Type | Article |
