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IgG allotypes and subclasses in Norwegian patients with multiple sclerosis

Content Provider	Semantic Scholar
Author	Raknes, Guttorm Filho, José Fernandes Pandey, Janardan P. Myhr, Kirsten Vedeler, Christian A.
Copyright Year	2000
Abstract	Multiple sclerosis (MS) is a multifactorial disease in which genetic and environmental factors apparently have a major influence on the susceptibility and course of the disease. In the present study we have investigated the genetic basis and subclass levels of IgG in MS. Hundred and thirty-six Norwegian patients with MS and 92 controls were genotyped for IgG allotypes of the GM and KM systems. IgG and IgG subclasses were quantified in sera from 115 MS patients and 20 controls. Neither GM nor KM allo-, haplo- or genotypes were significantly correlated with susceptibility, severity or course of the disease. The G1M (3) (3), G2M (23) (23) and G3M (5) (5) allotypes were significantly correlated with high serum levels of IgG3, whereas high IgG2 levels were correlated with G1M (3) (3) and G2M (23) (23) in both patients and controls. Serum levels of IgG subclasses were not significantly correlated with course or severity of the disease. The results indicate no major role for IgG allotypes or IgG subclass levels in the pathogenesis of MS.
Starting Page	111
Ending Page	115
Page Count	5
File Format	PDF HTM / HTML
DOI	10.1016/S0022-510X(00)00292-6
PubMed reference number	10831771
Journal	Medline
Volume Number	175
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0022510X00002926
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0022510X00002926?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/S0022-510X%2800%2900292-6
Journal	Journal of the Neurological Sciences
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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