Intrathecal synthesis of IgG subclasses in multiple sclerosis and in AIDS

Content Provider	Semantic Scholar
Author	Lambin, Patrick Gervais, Alice Levy, Michaël Defendini, Efraín Schuller, Elisabeth
Copyright Year	1991
Abstract	DETECTION OF IgG SUBCLASSES IN CEREBROSPINAL FLUID AND SERA OF PATIENTS WITH MULTIPLE SCLEROSIS AND ITS CLINICAL VALUE J. Los)', G. Michalowska-Wender, M. Wender Department of Neurology, University School of Medicine, Pozna6, Poland IgG1, IgG2, IgG3, and IgG4 subclasses were detected in cerebrospinai fluid and sera from 32 patients with MS, of whom 23 had relapsing-remitting and 9 chronic progressive course of the disease. Ten patients with diagnosis of neurasthenia, t=asion headache, epilepsy and syncope served as controls. The ELISA method with monoclonal antibodies sl~cific for human IgGl ! clone HP 60691, IgG2 / clone HI) 60141, IgG3 / clone 60471, IgG4 / clone ITP 6023/and double antibody avidin-biotin-peroxidase system has been applied. There was no statistical difference between values of lgG subclasses in MS and control sofa. The CSF levels of IgG1 and IgG3 in MS patients were higher than those of controls, whereas the levels of IgG2 and IgO4 between these two studied groups were not significantly different. The IgO1 and IgG3 indexes were significantly higher in MS patients than in controls, showing that among four IgG subclasses, IgG1 and IgO3 were synthesized in the central nervous system of patients with MS. The elevation of IgG1 and IgG3 indexes in MS patients was found more frequently/in about 90% of patients/than the elevation of IgG index/in only 72% of patients/.
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DOI	10.1016/0165-5728(91)91071-J
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/016557289191071J
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Alternate Webpage(s)	https://doi.org/10.1016/0165-5728%2891%2991071-J
Volume Number	35
Journal	Journal of Neuroimmunology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article