Serum Immunoglobulin G (IgG) Subclasses in a Cohort of Systemic Sclerosis Patients.

Content Provider	Europe PMC
Author	Pellicano, Chiara Colalillo, Amalia Cusano, Giuseppina Palladino, Andrea Pellegrini, Marica Callà, Cinzia Anna Maria Mazzuccato, Giorgia Carnazzo, Valeria Pignalosa, Stefano Di Biase, Luigi Marino, Mariapaola Basile, Umberto Rosato, Edoardo
Editor	Giuggioli, Dilia
Copyright Year	2023
Abstract	Objectives: To assess serum immunoglobulin G (IgG) subclasses in a cohort of systemic sclerosis (SSc) patients and to evaluate the influence of IgG subclasses in the main complications of the disease. Methods: The serum level of IgG subclasses was evaluated in 67 SSc patients and 48 healthy controls (HC), matched for sex and age. Serum samples were collected and measured IgG1–4 subclasses by turbidimetry. Results: SSc patients had lower median total IgG [9.88 g/l (IQR 8.18–11.42 g/l) vs. 12.09 g/l (IQR 10.24–13.54 g/l), p < 0.001], IgG1 [5.09 g/l (IQR 4.25–6.38 g/l) vs. 6.03 g/l (IQR 5.39–7.90 g/l), p < 0.001], and IgG3 [0.59 g/l (IQR 0.40–0.77 g/l) vs. 0.80 g/l (IQR 0.46–1 g/l), p < 0.05] serum levels compared to HC. The logistic regression analysis showed IgG3 as the only variable associated with the diffusing capacity of the lung for carbon monoxide (DLco) ≤60% of the predicted [OR 9.734 (CI 95%: 1.312–72.221), p < 0.05] and modified Rodnan skin score (mRSS) [OR 1.124 (CI 95%: 1.019–1.240), p < 0.05], anti-topoisomerase I [OR 0.060 (CI 95%: 0.007–0.535), p < 0.05], and IgG3 [OR 14.062 (CI 95%: 1.352–146.229), p < 0.05] as variables associated with radiological interstitial lung disease (ILD). Conclusion: SSc patients have reduced levels of total IgG and an altered IgG subclass distribution compared to HC. Moreover, SSc patients show different serum IgG subclasses profiles according to the main involvement of the disease.
Volume Number	13
PubMed Central reference number	PMC9961548
Issue Number	2
PubMed reference number	36836543
Journal	Journal of Personalized Medicine [J Pers Med]
e-ISSN	20754426
DOI	10.3390/jpm13020309
Language	English
Publisher	MDPI
Publisher Date	2023-02-10
Access Restriction	Open
Rights License	Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). © 2023 by the authors.
Subject Keyword	systemic sclerosis IgG subclasses ILD
Content Type	Text
Resource Type	Article
Subject	Medicine