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Dendrotoxin, 4-Aminopyridine, and ?-Bungarotoxin Act at Common Loci but by Two Distinct Mechanisms to Induce $Ca^{2+}$-Dependent Release of Glutamate from Guinea-Pig Cerebrocortical Synaptosomes
| Content Provider | Scilit |
|---|---|
| Author | Tibbs, Gareth R. Dolly, J. Oliver Nicholls, David G. |
| Copyright Year | 1989 |
| Description | Journal: Journal of Neurochemistry The release of endogenous glutamate from guinea-pig cerebrocortical synaptosomes evoked by dendrotoxin, beta-bungarotoxin, and 4-aminopyridine is compared. Dendrotoxin and 4-aminopyridine cause Ca2+-dependent release, representing a partial depletion of the KCl-releasable transmitter pool. The decrease in the plasma membrane potential caused by 4-aminopyridine or dendrotoxin and the evoked release of glutamate from a transmitter pool accord with the inhibitory action of these agents on certain K+ conductances. In contrast, the massive release of glutamate evoked by beta-bungarotoxin is produced in the presence of Ca2+ but not of Sr2+, a result consistent with a generalised permeabilisation of synaptosomal plasma membranes. Although dendrotoxin inhibits the binding of beta-bungarotoxin and the resultant synaptosomal lysis, demonstration of a direct effect of beta-bungarotoxin binding per se on K+ permeability is impractical owing to its phospholipase A2 activity. |
| Related Links | http://onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.1989.tb10917.x/pdf |
| Ending Page | 206 |
| Page Count | 6 |
| Starting Page | 201 |
| e-ISSN | 14714159 |
| DOI | 10.1111/j.1471-4159.1989.tb10917.x |
| Journal | Journal of Neurochemistry |
| Issue Number | 1 |
| Volume Number | 52 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 1989-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Journal of Neurochemistry Glutamate Release Plasma Membrane Potential |
| Content Type | Text |
| Resource Type | Article |
