NDLI: Anti-proliferative and apoptotic effects of Ziziphus Jujube on cervical and breast cancer cells.

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Anti-proliferative and apoptotic effects of Ziziphus Jujube on cervical and breast cancer cells.

Content Provider	Semantic Scholar
Author	Abedini, Mohammad Reza Erfanian, Nafiseh Nazem, Habibollah Jamali, Sara Hoshyar, Reyhane
Copyright Year	2016
Abstract	OBJECTIVE Ziziphus Jujube (Jujube) plant has exhibited numerous medicinal and pharmacological properties including antioxidant and anti-inflammatory effects. This study was carried out to investigate its anti-cancer and pro-apoptotic abilities in human cervical and breast cancer cells in vitro. MATERIALS AND METHODS The cervical OV2008 and breast MCF-7 cancer cells were incubated with different concentrations of Jujube aqueous extraction (0-3 mg/ml) for various times (0-72 h). Cell viability was assessed by Trypan Blue and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The expression of two apoptosis-related genes in treated cells evaluated by quantitative Real Time -PCR analysis. RESULTS Jujube significantly inhibited cancer cell viability in a dose- and time- dependent manner. Herb-induced apoptosis was associated with enhanced expression of Bax and decreased Bcl2 gene leading eventually to a time-dependent six fold increase in the Bax/Bcl-2 ratio. CONCLUSION These results indicated that Jujube may be a natural potential and promising agent to prevent or treat human cancers.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.sid.ir/en/VEWSSID/J_pdf/1019820160206.pdf
Alternate Webpage(s)	http://ajp.mums.ac.ir/pdf_5345_826725620370c6b335552dcb472088b6.html
Alternate Webpage(s)	http://ajp.mums.ac.ir/article_5345_5c2278e1042c0956d6019198fee16534.pdf
PubMed reference number	27222827v1
Volume Number	6
Issue Number	2
Journal	Avicenna journal of phytomedicine
Language	English
Access Restriction	Open
Subject Keyword	Apoptosis Cell Survival Cellular Phone Kilogram per Cubic Meter Mammary Neoplasms Neck Pharmacology Trypan Blue Ziziphus jujuba Ab.IgE:ACnc:Pt:Ser:Qn cancer cell incubated methscopolamine bromide monooxyethylene trimethylolpropane tristearate
Content Type	Text
Resource Type	Article

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