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Autonomic and Adrenocortical Reactivity and Buccal Cell Telomere Length in Kindergarten Children
| Content Provider | Scilit |
|---|---|
| Author | Kroenke, Candyce H. Epel, Elissa Adler, Nancy Bush, Nicole R. Obradović, Jelena Lin, Jue Blackburn, Elizabeth Stamperdahl, Juliet Lise Boyce, W. Thomas |
| Copyright Year | 2011 |
| Description | Journal: Psychosomatic Medicine |
| Abstract | Objective: To examine associations between autonomic nervous system and adrenocortical reactivity to laboratory stressors and buccal cell telomere length (BTL) in children. Methods: The study sample comprised 78 children, aged 5 to 6 years, from a longitudinal cohort study of kindergarten social hierarchies, biologic responses to adversity, and child health. Buccal cell samples and reactivity measures were collected in the spring of the kindergarten year. BTL was measured by real-time polymerase chain reaction, as the telomere-to-single-copy gene ratio. Parents provided demographic information; parents and teachers reported children's internalizing and externalizing behavior problems. Components of children's autonomic (heart rate, respiratory sinus arrhythmia [RSA], and preejection period [PEP]) and adrenocortical (salivary cortisol) responses were monitored during standardized laboratory challenges. We examined relationships between reactivity, internalizing and externalizing behaviors, and BTL, adjusted for age, race, and sex. Results: Heart rate and cortisol reactivity were inversely related to BTL, PEP was positively related to BTL, and RSA was unrelated to BTL. Internalizing behaviors were also inversely related to BTL (standardized β = −0.33, p =.004). Split at the median of reactivity parameters, children with high sympathetic activation (decreasing PEP), and parasympathetic withdrawal (decreasing RSA) did not differ with regard to BTL. However, children with both this profile and high cortisol reactivity (n = 12) had significantly shorter BTL (0.80 versus 1.00; χ2 = 7.6, p =.006), compared with other children. Conclusions: The combination of autonomic and adrenocortical reactivity was associated with shorter BTL in children. These data suggest that psychophysiological processes may influence, and that BTL may be a useful marker of, early biologic aging. DNA = deoxyribonucleic acid; BTL = buccal cell telomere length; ANS = autonomic nervous system; HPA = hypothalamic-pituitary-adrenal; HR = heart rate; SNS = sympathetic nervous system; PNS = parasympathetic nervous system; PEP = preejection period; RSA = respiratory sinus arrhythmia; PAWS = Peers and Wellness Study; BMI = body mass index; T/S = telomere repeat copy number to single-copy gene copy number; ECG = electrocardiograph; SES = socioeconomic status. |
| Related Links | http://europepmc.org/articles/pmc3212037?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3212037/pdf |
| Ending Page | 540 |
| Page Count | 8 |
| Starting Page | 533 |
| ISSN | 00333174 |
| e-ISSN | 15347796 |
| DOI | 10.1097/psy.0b013e318229acfc |
| Journal | Psychosomatic Medicine |
| Issue Number | 7 |
| Volume Number | 73 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2011-09-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Psychosomatic Medicine Pediatrics and Child Health Autonomic Reactivity, Adrenocortical Reactivity, Buccal Cell Telomeres, Internalizing, Stress, Children |
| Content Type | Text |
| Resource Type | Article |
| Subject | Developmental and Educational Psychology Applied Psychology Psychiatry and Mental Health |
