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Family Adversity and Autonomic Reactivity Association With Immune Changes in HIV-Affected School Children
| Content Provider | Scilit |
|---|---|
| Author | Thomas, Melanie R. Wara, Diane Saxton, Katherine Truskier, Mary Chesney, Margaret A. Boyce, W. Thomas |
| Copyright Year | 2013 |
| Description | Journal: Psychosomatic Medicine |
| Abstract | Objective To explore whether primary school entry is associated with changes in immune system parameters in HIV-affected children. HIV-affected children are vulnerable to psychosocial stressors, regardless of their own HIV serological status. Methods Data from 38 HIV-positive and 29 HIV-negative children born to seropositive women were obtained. Measures included family adversity questionnaires, autonomic nervous system (ANS) reactivity, and enumerative and functional changes in peripheral blood immune parameters. Results In comparison with children who were HIV-negative, children who were HIV-positive at baseline had fewer CD4+ T lymphocytes (mean [M] = 916 versus 1206 cells/mm3 × 103; F = 7.8, p = .007), more CD8+ cells (M = 1046 versus 720 cells/mm3 × 103; F = 7.98, p = .006), and diminished natural killer cell cytotoxicity (M = −0.29 versus 0.41; F = 8.87, p = .004). School entry was associated with changes in immune parameters, but HIV status was not associated with the magnitude of changes. Changes in immune parameters after school entry were associated with family stress and preschool entry ANS reactivity. Highly ANS reactive children had either the greatest increase in CD8+ cells after school entry or the greatest decrease, depending on reported levels of family adversity (B = 215.35; t = 3.74, p < .001). Changes in functional immune assays were significantly associated with the interactions between HIV status and ANS reactivity. Conclusions These results suggest that autonomic reactivity is associated with increased immunological sensitivity to adverse or challenging social contexts among children affected by HIV. |
| Related Links | http://europepmc.org/articles/pmc3830556?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830556/pdf |
| Ending Page | 565 |
| Page Count | 9 |
| Starting Page | 557 |
| ISSN | 00333174 |
| e-ISSN | 15347796 |
| DOI | 10.1097/psy.0b013e31829807fb |
| Journal | Psychosomatic Medicine |
| Issue Number | 6 |
| Volume Number | 75 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2013-07-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Psychosomatic Medicine Biomedical Social Sciences Hiv, Children, Stress, Reactivity, Immune |
| Content Type | Text |
| Resource Type | Article |
| Subject | Developmental and Educational Psychology Applied Psychology Psychiatry and Mental Health |
