NDLI: In Vivo Modulation of the N-Methyl-D-Aspartate Receptor Complex by D-Serine: Potentiation of Ongoing Neuronal Activity as Evidenced by Increased Cerebellar Cyclic GMP

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In Vivo Modulation of the N-Methyl-D-Aspartate Receptor Complex by D-Serine: Potentiation of Ongoing Neuronal Activity as Evidenced by Increased Cerebellar Cyclic GMP

Content Provider	Scilit
Author	Wood, Paul L. Emmett, Mark R. Rao, Tadimeti S. Mick, Steve Cler, Julie Iyengar, Smriti
Copyright Year	1989
Description	Journal: Journal of Neurochemistry Direct intracerebellar injections of N-methyl-D-aspartate (NMDA) or D-serine elicited dose-dependent increases in cerebellar cyclic GMP levels, in vivo in the mouse. The actions of D-serine were antagonized by the competitive NMDA receptor antagonist 3-(2-carboxypiperazin-4-yl) propyl-1-phosphonic acid and by the phencyclidine receptor agonist MK-801, observations supporting actions at the NMDA-coupled glycine receptor. In addition, the actions of D-serine were antagonized by a partial agonist (D-cycloserine) and an antagonist (HA-966) of the NMDA-coupled glycine receptor. These data are all consistent with D-serine acting at the NMDA-coupled glycine receptor and represent the first demonstration of glycine receptor potentiation of ongoing NMDA-mediated neuronal activity in the CNS, rather than potentiation of exogenous NMDA.
Related Links	http://onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.1989.tb11803.x/pdf
Ending Page	981
Page Count	3
Starting Page	979
e-ISSN	14714159
DOI	10.1111/j.1471-4159.1989.tb11803.x
Journal	Journal of Neurochemistry
Issue Number	3
Volume Number	53
Language	English
Publisher	Wiley-Blackwell
Publisher Date	1989-09-01
Access Restriction	Open
Subject Keyword	Journal: Journal of Neurochemistry Cerebellar Cyclic Gmp N‐methyl‐d‐aspar‐tate‐coupled Glycine Receptor 3‐(2‐carboxypiperazin‐4‐yl)propyl‐1 ‐phosphonic Acid 1 ‐hydroxy‐3‐aminopyrrolidone‐2
Content Type	Text
Resource Type	Article

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3-[(±)-2-Carboxypiperazin-4-yl]propyl-1-Phosphonic Acid Recognizes Two N-Methyl-D-Aspartate Binding Sites in Rat Cerebral Cortex Membranes

Localization of N-Methyl-d-Aspartate Receptors in the Rat Striatum: Effects of Specific Lesions on the [3H]3-(2-Carboxypiperazin-4-yl)propyl-1-Phosphonic Acid Binding

Regionally Distinct N-Methyl-D-Aspartate Receptors Distinguished by Quantitative Autoradiography of $[^{3}$H]MK-801 Binding in Rat Brain

The Glycine Site of the N-Methyl-D-Aspartate Receptor Channel: Differences Between the Binding of HA-966 and of 7-Chlorokynurenic Acid

Stereoselectivity for the (R)-Enantiomer of HA-966 (l-Hydroxy-3-Aminopyrrolidone-2) at the Glycine Site of the N-Methyl-d-Aspartate Receptor Complex

N-Methyl-D-Aspartate Receptors and Ethanol: Inhibition of Calcium Flux and Cyclic GMP Production

HA-996 (1-hydroxy-3-aminopyrrolidone-2) selectively reduces N-methyl-d-aspartate (NMDA)-mediated brain damage

3-((±)2-Carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP) more potently antagonizes the high-affinity Mg2+ binding site on the N-methyl-d-aspartatephencyclidine receptor ion channel complex than the l-glutamate recognition site

Neurochemical Interactions of Competitive N-Methyl-D-Aspartate Antagonists with Dopaminergic Neurotransmission and the Cerebellar Cyclic GMP System: Functional Evidence for a Phasic Glutamatergic Control of the Nigrostriatal Dopaminergic Pathway

In Vivo Modulation of the N-Methyl-D-Aspartate Receptor Complex by D-Serine: Potentiation of Ongoing Neuronal Activity as Evidenced by Increased Cerebellar Cyclic GMP

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In Vivo Modulation of the N-Methyl-D-Aspartate Receptor Complex by D-Serine: Potentiation of Ongoing Neuronal Activity as Evidenced by Increased Cerebellar Cyclic GMP