NDLI: HA-996 (1-hydroxy-3-aminopyrrolidone-2) selectively reduces N-methyl-d-aspartate (NMDA)-mediated brain damage

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HA-996 (1-hydroxy-3-aminopyrrolidone-2) selectively reduces N-methyl-d-aspartate (NMDA)-mediated brain damage

Content Provider	Semantic Scholar
Author	Mcdonald, John W. Uckele, John E. Silverstein, Faye S. Johnston, Michael V.
Copyright Year	1989
Abstract	The neuroprotective effects of the strychnine-insensitive glycine receptor antagonist, HA-966, against N-methyl-D-aspartate (NMDA)- and quisqualate (QA)-mediated brain injury were determined in perinatal rats. Postnatal day (PND) 7 rats received intrastriatal injections of NMDA (25 nmol) or QA (100 nmol) and then were administered intraperitoneal (i.p.) injections of varying doses of HA-966 or vehicle 15 min later. Animals were sacrificed 5 days later and the degree of brain injury was calculated by comparison of the weights of injected and contralateral cerebral hemispheres. HA-966 selectively reduced the degree of NMDA-mediated brain injury in a dose-dependent manner. However, HA-966 did not attenuate QA-mediated brain injury.
Starting Page	167
Ending Page	170
Page Count	4
File Format	PDF HTM / HTML
DOI	10.1016/0304-3940(89)90349-2
PubMed reference number	2682393
Journal	Medline
Volume Number	104
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/0304394089903492
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/0304394089903492?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://deepblue.lib.umich.edu/bitstream/handle/2027.42/27755/0000148.pdf?isAllowed=y&sequence=1
Alternate Webpage(s)	https://doi.org/10.1016/0304-3940%2889%2990349-2
Journal	Neuroscience Letters
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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The Glycine Site of the N-Methyl-D-Aspartate Receptor Channel: Differences Between the Binding of HA-966 and of 7-Chlorokynurenic Acid

Stereoselectivity for the (R)-Enantiomer of HA-966 (l-Hydroxy-3-Aminopyrrolidone-2) at the Glycine Site of the N-Methyl-d-Aspartate Receptor Complex

In Vivo Modulation of the N-Methyl-D-Aspartate Receptor Complex by D-Serine: Potentiation of Ongoing Neuronal Activity as Evidenced by Increased Cerebellar Cyclic GMP

Ethanol Inhibition ofN-Methyl-d-aspartate Receptors Is Reduced by Site-directed Mutagenesis of a Transmembrane Domain Phenylalanine Residue

An α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Antagonist and an N-Methyl-D-aspartate (NMDA) Channel Blocker Synergistically Impair Spatial Memory in Rats

Dynamic Regulation of N-Methyl-d-aspartate (NMDA) and α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors by Posttranslational Modifications

Glutathione Is an Endogenous Ligand of Rat Brain N-Methyl-D-Aspartate (NMDA) and 2-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionate (AMPA) Receptors

Interaction of aquaporin 4 and N-methyl-D-aspartate NMDA receptor 1 in traumatic brain injury of rats

Interaction of aquaporin 4 and N-methyl-D-aspartate NMDA receptor 1 in traumatic brain injury of rats.

HA-996 (1-hydroxy-3-aminopyrrolidone-2) selectively reduces N-methyl-d-aspartate (NMDA)-mediated brain damage

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The Glycine Site of the N-Methyl-D-Aspartate Receptor Channel: Differences Between the Binding of HA-966 and of 7-Chlorokynurenic Acid

Stereoselectivity for the (R)-Enantiomer of HA-966 (l-Hydroxy-3-Aminopyrrolidone-2) at the Glycine Site of the N-Methyl-d-Aspartate Receptor Complex

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HA-996 (1-hydroxy-3-aminopyrrolidone-2) selectively reduces N-methyl-d-aspartate (NMDA)-mediated brain damage