Loading...
Please wait, while we are loading the content...
Similar Documents
3-((±)2-Carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP) more potently antagonizes the high-affinity Mg2+ binding site on the N-methyl-d-aspartatephencyclidine receptor ion channel complex than the l-glutamate recognition site
| Content Provider | Semantic Scholar |
|---|---|
| Author | Hatta, Kotaro Yamamato, T. Hori, Takamitsu Okuwa, Masayuki Moroji, Takashi |
| Copyright Year | 1991 |
| Abstract | Using frozen-thawed and extensively washed rat cortical membranes, the effects of 3-((+/-)2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP) on [3H]N-(1-[2-thienyl]cyclohexyl)-3,4-piperidine ([3H]TCP) binding stimulated by either 1 microM L-glutamate or 300 microM Mg2+ were examined. CPP much more potently inhibited Mg(2+)-stimulated [3H]TCP binding than [3H]TCP binding stimulated by L-glutamate, suggesting that CPP preferentially acts at Mg2+ recognition sites with high affinity, which may be anatomically and/or functionally associated with a recognition site for N-methyl-D-asparate (NMDA) antagonists. |
| Starting Page | 229 |
| Ending Page | 231 |
| Page Count | 3 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0304-3940(91)90100-8 |
| PubMed reference number | 1712440 |
| Journal | Medline |
| Volume Number | 124 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/0304394091901008 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/0304394091901008?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/0304-3940%2891%2990100-8 |
| Journal | Neuroscience Letters |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
