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Maizels, “Expansion and activation of CD4 + CD25 + regulatory T cells in Heligmosomoides polygyrus infection
| Content Provider | CiteSeerX |
|---|---|
| Author | Finney, Constance A. M. Taylor, Matthew D. Wilson, Mark S. Maizels, Rick M. |
| Description | Regulatory T cell responses to infectious organisms influence not only immunity and immunopathology, but also responses to bystander antigens. Mice infected with the gastrointestinal nematode parasite Heligmosomoides polygyrus show an early Th2dominated immune response (days 7–14), but by day 28 a strongly regulatory profile is evident with antigen-specific IL-10 release and elevated frequency of CD4 + T cells bearing surface TGF-b. CD4 + CD25 + T cells from infected mice show enhanced capacity to block in vitro effector T cell proliferation. CD4 + CD25 + cell numbers expand dramatically during infection, with parallel growth of both CD25 + Foxp3 + and CD25 + Foxp3 – subsets. CTLA-4 and glucocorticoid-induced tolerance-associated receptor, also associated with regulatory T cell function, become more prominent, due to both expanded CD25 + cell numbers and increased expression among the CD25 – population. Both intensity and frequency of CD103 expression by CD4 + T cells rise significantly, with greatest expansion among CD25 + Foxp3 + cells. While TGF-b expression is observed among both CD25 + Foxp3 + and CD25 + Foxp3 – subsets, it is the latter population which shows higher TGF-b staining following infection. These data demonstrate in a chronic helminth infection that Foxp3 + regulatory T cells are stimulated, increasing CD103 expression in particular, but that significant changes occur to other populations including expansion of CD25 + TGF-b + Foxp3 – cells, and induction of CTLA-4 on CD25 – non-regulatory lymphocytes. |
| File Format | |
| Language | English |
| Publisher Institution | 1874–1886, 2007. of Biomedicine and Biotechnology 9 |
| Access Restriction | Open |
| Subject Keyword | Vitro Effector Cell Proliferation Chronic Helminth Infection Infected Mouse Show Cd103 Expression Cd25 Non-regulatory Lymphocyte Data Demonstrate Tgf-b Staining Significant Change Antigen-specific Il-10 Release Heligmosomoides Polygyrus Infection Cd4 Cell Cd25 Foxp3 Elevated Frequency Cd25 Foxp3 Subset Glucocorticoid-induced Tolerance-associated Receptor Cd4 Cd25 Regulatory Cell Cd4 Cell Rise Cd4 Cd25 Cell Number Tgf-b Expression Increased Expression Parallel Growth Cd4 Cd25 Cell Cd25 Cell Number Regulatory Cell Response Regulatory Profile Cd25 Tgf-b Foxp3 Cell Cd25 Population Foxp3 Regulatory Cell Early Th2dominated Immune Response Cd25 Foxp3 Cell Surface Tgf-b Latter Population Infectious Organism Influence Regulatory Cell Function |
| Content Type | Text |
| Resource Type | Article |
