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CD4+CD25+Foxp3+ T Cells and CD4+CD25−Foxp3+ T Cells in Aged Mice
| Content Provider | Scilit |
|---|---|
| Author | Nishioka, Tomohisa Shimizu, Jun Iida, Ryuji Yamazaki, Sayuri Sakaguchi, Shimon |
| Copyright Year | 2006 |
| Description | Aging is associated with a progressive decline in T cell-mediated immune responses. However, it has been unknown whether regulatory/suppressive CD4 T cells are involved in this decline. Our in vitro analyses revealed that $CD4^{+}CD25^{+}$ T cells, the well-characterized naturally occurring regulatory/suppressive CD4 T cells, in aged mice are functionally comparable to those in young mice (i.e., anergic and suppressive), although slightly increased in number. In contrast, functional changes to whole $CD4^{+}CD25^{−}$ T cells were pronounced in aged mice, i.e., the majority of aged $CD4^{+}CD25^{−}$ T cells exhibited a significant hyporesponsiveness, and the remaining cells maintained a normal responsiveness. Furthermore, we identified Foxp3 (a transcription factor critical in conferring the regulatory/suppressive function to CD4 T cells)-positive suppressive CD4 T cells among aged hyporesponsive $CD4^{+}CD25^{−}$ T cells. These results suggest that the age-related decline in T cell-mediated immune responses is ascribable to changes in the $CD4^{+}CD25^{−}$ T cell population and not to a functional augmentation of suppressive $CD4^{+}CD25^{+}$ T cells. |
| Ending Page | 6593 |
| Page Count | 8 |
| Starting Page | 6586 |
| ISSN | 00221767 |
| e-ISSN | 15506606 |
| DOI | 10.4049/jimmunol.176.11.6586 |
| Journal | The Journal of Immunology |
| Issue Number | 11 |
| Volume Number | 176 |
| Language | English |
| Publisher | The American Association of Immunologists |
| Publisher Date | 2006-06-01 |
| Access Restriction | Open |
| Subject Keyword | Transcription Factor Cd4 T Cells Cell Mediated Immune Mediated Immune Responses |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
