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Occult hepatitis B virus infection in immunocompromised patients
| Content Provider | Scilit |
|---|---|
| Author | Jardim, Ruth Nogueira Cordeiro Moraes Gonçales, Neiva Sellan Lopes Pereira, Josiane Silveira Felix Fais, Viviane Cristina Junior, Fernando Lopes Gonçales |
| Copyright Year | 2008 |
| Description | Occult hepatitis B infection is characterized by hepatitis B virus (HBV) DNA in the serum in the absence of hepatitis B surface antigen (HBsAg). We assessed occult HBV infection prevalence in two groups of immunocompromised patients (maintenance hemodialysis patients and HIV-positive patients) presenting HBsAg-negative and anti-HBc positive serological patterns, co-infected or not by HCV. Thirty-four hemodialysis anti-HIV negative patients, 159 HIV-positive patients and 150 blood donors who were anti-HBc positive (control group) were selected. HBV-DNA was detected by nested-PCR. Occult hepatitis B infection was not observed in the hemodialysis patients group but was found in 5% of the HIV-patients and in 4% of the blood donors. Immunosuppression in HIV positive patients was not a determining factor for occult HBV infection. In addition, no significant relationship between HBV-DNA and HCV co-infection in the HIV-positive patient group was found. A lack of significant associations was also observed between positivity for HBV-DNA and CD4 count, viral load and previous lamivudine treatment in these HIV-positive patients |
| Related Links | http://www.scielo.br/pdf/bjid/v12n4/a08v12n4.pdf http://www.scielo.br/scielo.php?script=sci_pdf&pid=S1413-86702008000400008&lng=en&nrm=iso&tlng=en |
| Ending Page | 305 |
| Page Count | 6 |
| Starting Page | 300 |
| ISSN | 14138670 |
| e-ISSN | 16784391 |
| DOI | 10.1590/s1413-86702008000400008 |
| Journal | The Brazilian Journal of Infectious Diseases |
| Issue Number | 4 |
| Volume Number | 12 |
| Language | English |
| Publisher | FapUNIFESP (SciELO) |
| Publisher Date | 2008-08-01 |
| Access Restriction | Open |
| Subject Keyword | The Brazilian Journal of Infectious Diseases Viral Load Hepatitis B Virus |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Microbiology (medical) |
