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Delta Infection and Hepatitis B Virus Replication in Danish Patients with Fulminant Hepatitis B
| Content Provider | Scilit |
|---|---|
| Author | Krogsgaard, Kim Mathiesen, Lars R. Aldershvile, Jan Kryger, Peter Andersson, Poul Hansson, Bengt-Göran Nielsen, Jens O. Ranek, Leo |
| Copyright Year | 1988 |
| Description | The presence of hepatitis B virus and delta agent markers was investigated in 41 patients referred during the years 1970–1985 with fulminant hepatitis classified as type B or non-A non-B and compared to findings in patients with uncomplicated hepatitis B and chronic hepatitis B infection. 13 patients had no markers of hepatitis B and delta infection and were classified as non-A non-B hepatitis. The remaining 28 patients were all HBsAg and IgM anti-HBc positive and 14 (50%) had evidence of delta infection. In contrast, only 13/71 patients (18%) with acute benign hepatitis B had evidence of delta coinfection (p<0.005). This corresponds to an odds ratio of 4.5 for development of fulminant hepatitis among patients with hepatitis B and delta coinfection. In 100 chronic HBsAg carriers 29% were positive for delta markers. 12 of the delta infected patients with fulminant hepatitis were positive for total antibody to the delta antigen, and 2 were delta antigen positive. Three were HBeAg positive/anti-HBe negative. None had hepatitis B virus DNA. Among the 14 patients without delta infection, hepatitis B virus DNA was found in 2/4 HBeAg positive/anti-HBe negative patients and in 1/8 patients negative for both markers. The present data indicate that a high proportion of Danish patients with fulminant hepatitis B have hepatitis B and delta agent coinfection. Further, the findings suggest that hepatitis B and delta coinfection may be associated with an increased risk of development of fulminant hepatitis as compared to that of hepatitis B alone. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/00365548809032428 |
| Ending Page | 133 |
| Page Count | 7 |
| Starting Page | 127 |
| ISSN | 00365548 |
| e-ISSN | 16511980 |
| DOI | 10.3109/00365548809032428 |
| Journal | Scandinavian journal of infectious diseases |
| Issue Number | 2 |
| Volume Number | 20 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1988-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Scandinavian Journal of Infectious Diseases Infectious Diseases Hepatitis B Virus Virus Replication Delta Infection Fulminant Hepatitis Danish Patients |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Immunology and Microbiology Microbiology (medical) |
