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Improving the therapeutic efficiency of noncoding RNAs in cancers using targeted drug delivery systems
| Content Provider | Scilit |
|---|---|
| Author | Alzhrani, Rami Alsaab, Hashem O. Petrovici, Alex Bhise, Ketki Vanamala, Kushal Sau, Samaresh Krinock, Matthew J. Iyer, Arun K. |
| Copyright Year | 2020 |
| Description | Journal: Drug discovery today The delivery of noncoding (nc)RNA to target cancer stem cells and metastatic tumors has shown many positive outcomes, resulting in improved and more efficient treatment strategies. The success of therapeutic RNA depends solely on passing cellular barriers to reach the target site, where it binds to the mRNA of the interest. By 2018, 20 clinical trials had been initiated, most focusing on cancer and diabetes, with some progressing to Phase II clinical trials testing the safety and efficacy of small interfering (si)RNA. Many challenges limit RNA interference (RNAi) and miRNA usage in vivo; therefore, various approaches have been developed to promote ncRNA efficiency and stability. In this review, we focus on targeting the tumor microenvironment (TME) via the modification of delivery systems utilizing nanotechnology-based delivery approaches. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200292/pdf |
| Ending Page | 730 |
| Page Count | 13 |
| Starting Page | 718 |
| ISSN | 13596446 |
| e-ISSN | 18785832 |
| DOI | 10.1016/j.drudis.2019.11.006 |
| Journal | Drug discovery today |
| Issue Number | 4 |
| Volume Number | 25 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2020-04-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Drug discovery today Pharmacology and Pharmacy |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Pharmacology |
