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Novel approaches for the delivery of therapeutics in ischemic stroke
| Content Provider | Scilit |
|---|---|
| Author | Nozohouri, Saeideh Sifat, Ali Ehsan Vaidya, Bhuvaneshwar Abbruscato, Thomas J. |
| Copyright Year | 2020 |
| Description | Journal: Drug discovery today Ischemic stroke is one of the leading causes of death and disability worldwide. Current therapeutic options for stroke are use of tPA or endovascular thrombectomy. Multiple cellular and molecular mechanisms are involved in stroke pathophysiology. Recently novel approaches of drug delivery to the ischemic brain are being explored. Delivery of neuroprotectants to salvageable penumbra could improve stroke outcome. Ischemic stroke, a prominent cause of mortality and disability, is a combination of neuronal and vascular disorders. Reperfusion techniques, such as administration of tissue-plasminogen activator (t-PA) and endovascular mechanical thrombectomy, are commonly used treatment approaches. In recent years, interest has focused on saving the salvageable penumbra using neuroprotective strategies to improve long-term stroke outcomes. However, insufficient drug delivery to the ischemic brain, especially to penumbra, remains one of the major obstacles. Several novel approaches have been investigated to improve brain delivery. In this review, we discuss different novel drug delivery approaches explored by researchers in recent years for improved treatment of ischemic stroke. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7490972/pdf |
| Ending Page | 551 |
| Page Count | 17 |
| Starting Page | 535 |
| ISSN | 13596446 |
| e-ISSN | 18785832 |
| DOI | 10.1016/j.drudis.2020.01.007 |
| Journal | Drug discovery today |
| Issue Number | 3 |
| Volume Number | 25 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2020-01-21 |
| Access Restriction | Open |
| Subject Keyword | Journal: Drug discovery today Pharmacology and Pharmacy Ischemic Stroke Drug Delivery Approaches Novel Approaches of Drug Delivery |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Pharmacology |
