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Recent advances in hyaluronic acid-decorated nanocarriers for targeted cancer therapy
| Content Provider | Scilit |
|---|---|
| Author | Wickens, Jennifer M. Alsaab, Hashem O. Kesharwani, Prashant Bhise, Ketki Amin, Mohd Cairul Iqbal Mohd Tekade, Rakesh Kumar Gupta, Umesh Iyer, Arun K. |
| Copyright Year | 2017 |
| Description | Journal: Drug Discovery Today The cluster-determinant 44 (CD44) receptor has a high affinity for hyaluronic acid (HA) binding and is a desirable receptor for active targeting based on its overexpression in cancer cells compared with normal body cells. The nanocarrier affinity can be increased by conjugating drug-loaded carriers with HA, allowing enhanced cancer cell uptake via the HA-CD44 receptor-mediated endocytosis pathway. In this review, we discuss recent advances in HA-based nanocarriers and micelles for cancer therapy. In vitro and in vivo experiments have repeatedly indicated HA-based nanocarriers to be a target-specific drug and gene delivery platform with great promise for future applications in clinical cancer therapy. |
| Related Links | http://europepmc.org/articles/pmc5413407?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413407/pdf |
| Ending Page | 680 |
| Page Count | 16 |
| Starting Page | 665 |
| ISSN | 13596446 |
| e-ISSN | 18785832 |
| DOI | 10.1016/j.drudis.2016.12.009 |
| Journal | Drug Discovery Today |
| Issue Number | 4 |
| Volume Number | 22 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2017-04-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Drug Discovery Today Pharmacology and Pharmacy Targeted Drug Delivery |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Pharmacology |
