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Cough in Patients With Lung Cancer
| Content Provider | Scilit |
|---|---|
| Author | Harle, Amélie S. M. Blackhall, Fiona H. Molassiotis, Alex Yorke, Janelle Dockry, Rachel Holt, Kimberley J. Yuill, Danielle Baker, Katie Smith, Jaclyn A. |
| Copyright Year | 2018 |
| Description | Journal: Chest Cough is common in patients with lung cancer and current antitussive treatments are suboptimal. There is little published data describing cough in patients with lung cancer or work assessing clinical associations; the aim of the current is study is to fill that gap. Longitudinal prospective observational single-cohort study over 60 days. Patients were assessed through self-reported validated scales and, in a subsample, ambulatory cough monitoring, at study entry (day 0), day 30 and day 60. At study entry, 177 patients were included and 153 provided data at day 60. The median duration of cough was 52 weeks (IQR 8.5-260). Cough was described as severe enough to warrant treatment in 62% of the patients. Depending on the scale used, performance status was associated with both cough severity and cough impact (p<0.001) at study entry, while higher cough severity at study entry was associated with female sex (p=0.02), asthma (p=0.035), and reflux disease (p<0.001); cough impact at study entry was additionally associated with experiencing nausea (p=0.018). Cancer characteristics (i.e. cancer stage, histology) were not associated with cough severity nor cough impact; neither was smoking or COPD. This is the first study to describe characteristics of cough in patients with lung cancer and identify clinical associations that may be relevant for its treatment. Our data suggest that cough is a frequent and distressing symptom, and an unmet clinical need. Its associationwith gastro-intestinal symptoms in this study may improve our understanding of pathophysiology and therapeutic options for cough occurring in patients with lung cancer. |
| Related Links | https://www.research.manchester.ac.uk/portal/files/82423574/CLiC_CHEST_Manuscript_Accepted_version.pdf http://journal.chestnet.org/article/S0012369218325741/pdf |
| Ending Page | 113 |
| Page Count | 11 |
| Starting Page | 103 |
| ISSN | 00123692 |
| e-ISSN | 19313543 |
| DOI | 10.1016/j.chest.2018.10.003 |
| Journal | Chest |
| Issue Number | 1 |
| Volume Number | 155 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2019-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Chest Respiratory System Lung Cancer |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pulmonary and Respiratory Medicine Critical Care and Intensive Care Medicine Cardiology and Cardiovascular Medicine |
