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Racial and Ethnic Disparities in Early-Stage Lung Cancer Survival
| Content Provider | Scilit |
|---|---|
| Author | Soneji, Samir Tanner, Nichole T. Silvestri, Gerard A. Lathan, Christopher S. Black, William |
| Copyright Year | 2017 |
| Description | Journal: Chest Black patients with lung cancer diagnosed at early stages-for which surgical resection offers a potential cure-experience worse overall survival than do their white counterparts. We undertook a population-based study to estimate the racial and ethnic disparity in death from competing causes and assessed its contribution to the gap in overall survival among patients with early-stage lung cancer. We collected survival time data for 105,121 Hispanic, non-Hispanic Asian, non-Hispanic black, and non-Hispanic white patients with early-stage (IA, IB, IIA, and IIB) lung cancer diagnosed between 2004 and 2013 from the Surveillance, Epidemiology, and End-Results registries. We modeled survival time using competing risk regression and included as covariates sex, age at diagnosis, race/ethnicity, stage at diagnosis, histologic type, type of surgical resection, and radiation sequence. Adjusting for demographic, clinical, and treatment characteristics, non-Hispanic blacks experienced worse overall survival compared with non-Hispanic whites (adjusted hazard ratio [aHR], 1.05; 95% CI, 1.02-1.08), whereas Hispanics and non-Hispanic Asians experienced better overall survival (aHR, 0.93; 95% CI, 0.89-0.98; and aHR, 0.82; 95% CI, 0.79-0.86, respectively). Worse survival from competing causes of death, such as cardiovascular disease and other cancers-rather than from lung cancer itself-led to the disparity in overall survival among non-Hispanic blacks (adjusted relative risk, 1.07; 95% CI, 1.02-1.12). Narrowing racial and ethnic disparities in survival among patients with early-stage lung cancer will rely on more than just equalizing access to surgical resection and will need to include better management and treatment of smoking-related comorbidities and diseases. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812758/pdf |
| Ending Page | 597 |
| Page Count | 11 |
| Starting Page | 587 |
| ISSN | 00123692 |
| e-ISSN | 19313543 |
| DOI | 10.1016/j.chest.2017.03.059 |
| Journal | Chest |
| Issue Number | 3 |
| Volume Number | 152 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2017-09-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Chest Radiology, Nuclear Medicine and Imaging Respiratory System Lung Cancer Surgical Oncology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pulmonary and Respiratory Medicine Critical Care and Intensive Care Medicine Cardiology and Cardiovascular Medicine |
