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Alzheimer’s Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection
| Content Provider | Scilit |
|---|---|
| Author | Eimer, William A. Kumar, Deepak Kumar Vijaya Shanmugam, Nanda Kumar Navalpur Rodriguez, Alex S. Mitchell, Teryn Washicosky, Kevin J. György, Bence Breakefield, Xandra O. Tanzi, Rudolph E. Moir, Robert D. |
| Copyright Year | 2018 |
| Description | Journal: Neuron Summary Amyloid-β peptide (Aβ) fibrilization and deposition as β-amyloid are hallmarks of Alzheimer's disease (AD) pathology. We recently reported Aβ is an innate immune protein that protects against fungal and bacterial infections. Fibrilization pathways mediate Aβ antimicrobial activities. Thus, infection can seed and dramatically accelerate β-amyloid deposition. Here, we show Aβ oligomers bind herpesvirus surface glycoproteins, accelerating β-amyloid deposition and leading to protective viral entrapment activity in 5XFAD mouse and 3D human neural cell culture infection models against neurotropic herpes simplex virus 1 (HSV1) and human herpesvirus 6A and B. Herpesviridae are linked to AD, but it has been unclear how viruses may induce β-amyloidosis in brain. These data support the notion that Aβ might play a protective role in CNS innate immunity, and suggest an AD etiological mechanism in which herpesviridae infection may directly promote Aβ amyloidosis. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075814/pdf http://www.cell.com/article/S0896627318305269/pdf |
| e-ISSN | 10974199 |
| DOI | 10.1016/j.neuron.2018.06.030 |
| Journal | Neuron |
| Issue Number | 1 |
| Volume Number | 99 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2018-07-01 |
| Access Restriction | Open |
| Subject Keyword | Β-amyloid Peptide Alzheimer's Disease Antimicrobial Peptide Herpes Simplex Virus 1 Human Herpesvirus 6 Herpesvirus Glycoprotein |
| Content Type | Text |
| Resource Type | Article |
