Alzheimer’s Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection

Content Provider	Semantic Scholar
Author	Eimer, William A. Kumar, Deepak Kumar Vijaya Shanmugam, Nanda Kumar Navalpur Rodriguez, Alex S. Moir, Robert D.
Copyright Year	2018
Abstract	(Neuron 99, 56–63.e1–e3; July 11, 2018) In the original publication, our report titled ‘‘Alzheimer’s disease-associated b-amyloid is rapidly seeded by herpesviridae to protect against brain infection’’ by Eimer et al. (2018) (Neuron 99, 56–63, 10.1016/j.neuron.2018.06.030) contained typographical errors and insufficient methodological details. We are now providing additional methodological details in the online version of the manuscript and correct the following inaccuracies. First, in Figure 1 and accompanying Results section text, the wild type (WT) sample size (n) should be reported as ‘‘n = 9’’ and not ‘‘n = 11.’’ Second, Figure 1B incorrectly shows a p value (p) of ‘‘p = 0.026.’’ The correct value is ‘‘p = 0.013.’’ Third, inMethodDetails under ‘‘ADmouse infectionmodel,’’ a volume of 0.2mL is reported for bilateral injections of herpes simplex virus type I (HSV1) into mouse brain. The correct injection volume is 2 mL. Fourth, all antibodies to herpes glycoproteins were used in experiments at a concentration of 1 mg/mL. Antibodies to herpes glycoprotein B, C, E, H, and G were prepared from 1 mg/mL stocks by a 1:1,000 dilution. Herpes glycoprotein D antibody was prepared by a 1:100 dilution of a 0.1 mg/mL stock solution. Fifth, the three scale bars labeled ‘‘100 nm’’ in Figure 4A should read ‘‘200 nm.’’ Sixth, the scale bar for Figure 4B should be labeled ‘‘10 mm,’’ not ‘‘10 nm.’’ Seventh, in Figure S3A, the correct value for the scale bar is ‘‘200 nm,’’ not ‘‘50 nm.’’ The errors identified here do not alter the report’s analysis or conclusions, and these textual corrections, as well as the revised figures, now appear in the online version of this manuscript.
Starting Page	1527
Ending Page	1532
Page Count	6
File Format	PDF HTM / HTML
DOI	10.1016/j.neuron.2018.11.043
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0896627318310742
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0896627318310742?dgcid=api_sd_search-api-endpoint
PubMed reference number	30571943
Alternate Webpage(s)	https://doi.org/10.1016/j.neuron.2018.11.043
Journal	Medline
Volume Number	100
Journal	Neuron
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article