Alignment of Alzheimer's Disease Amyloid-β Peptide and Herpes Simplex Virus-1 pUL15 C-Terminal Nuclease Domain.

Content Provider	Europe PMC
Author	Lehrer, Steven Rheinstein, Peter H.
Copyright Year	2020
Abstract	Background:The cause of Alzheimer’s disease (AD) is poorly understood. Neurotropic microbes, particularly herpesviruses, might set off chronic neuroinflammation. Amyloid-β (Aβ) has antimicrobial properties and could represent a brain defense against infection.Objective:We searched for protein sequence alignment between herpes simplex virus type I (HSV-1) HSV-2, and Aβ.Methods:Protein data bank (pdb) structures for Aβ, HSV-1, and HSV-2 were searched on the RCSB Protein Data Bank. The protein structures were superimposed and aligned on PYMOL v 2.3.4.Results:For HSV-1 and Aβ, amino acid residues ser549 – his569 of HSV-1 aligned closely with residues asp7 - asn27 of Aβ. For HSV-2 and Aβ, amino acid residues of HSV-2 aligned less closely than those of HSV-1 with residues of Aβ.Conclusion:Conjugating and binding to the same alpha helix in the HSV-1 protease, Aβ could be marking HSV-1 for attack by the immune system, providing a rapid inherited immune response to a destructive neurotropic virus that would otherwise require the more time-consuming involvement of T-cells, B-cells, and the adaptive immune system. But older people do not respond to viral infections as well as younger individuals. When HSV-1 infection advances in an old person, more and more amyloid is produced, forming an adhesive web. As the brain tries to hold the pathologic process in check, neuroinflammation increases and spreads. Progressive neurodegeneration and cognitive decline are the outcome.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7592838&blobtype=pdf
Journal	Journal of Alzheimer's Disease Reports [J Alzheimers Dis Rep]
Volume Number	4
PubMed Central reference number	PMC7592838
Issue Number	1
PubMed reference number	33163898
e-ISSN	25424823
DOI	10.3233/adr-200231
Language	English
Publisher	IOS Press
Publisher Date	2020-09-09
Publisher Place	Nieuwe Hemweg 6B, 1013 BG Amsterdam, The Netherlands
Access Restriction	Open
Rights License	This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. © 2020 – IOS Press and the authors. All rights reserved
Subject Keyword	Alignment Alzheimer’s disease amyloid-β protein virus
Content Type	Text
Resource Type	Article
Subject	Geriatrics and Gerontology Clinical Psychology Neuroscience Psychiatry and Mental Health