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Influence of surfactants on depsipeptide submicron particle formation

Content Provider	Scilit
Author	Brunacci, Nadia Wischke, Christian Naolou, Toufik Neffe, Axel T. Lendlein, Andreas
Copyright Year	2017
Description	Journal: European Journal of Pharmaceutics and Biopharmaceutics Surfactants are required for the formation and stabilization of hydrophobic polymeric particles in aqueous environment. In order to form submicron particles of varying sizes from oligo[3-(S)-sec-butylmorpholine-2,5-dione]diols ((OBMD)-diol), different surfactants were investigated. As new surfactants, four-armed star-shaped oligo(ethylene glycol)s of molecular weights of 5-20kDa functionalized with desamino-tyrosine (sOEG-DAT) resulted in smaller particles with lower PDI than with desaminotyrosyl tyrosine (sOEG-DATT) in an emulsion/solvent evaporation method. In a second set of experiments, sOEG-DAT of M=10kDa was compared with the commonly employed emulsifiers polyvinylalcohol (PVA), polyoxyethylene (20) sorbitan monolaurate (Tween 20), and D-α-tocopherol polyethylene glycol succinate (VIT E-TPGS) for OBMD particle preparation. sOEG-DAT allowed to systematically change sizes in a range of 300 up to 900nm with narrow polydispersity, while in the other cases, a lower size range (250-400nm, PVA; ∼300nm, Tween 20) or no effective particle formation was observed. The ability of tailoring particle size in a broad range makes sOEG-DAT of particular interest for the formation of oligodepsipeptide particles, which can further be investigated as drug carriers for controlled delivery.
Related Links	http://www.hzg.de/imperia/md/content/gkss/zentrale_einrichtungen/bibliothek/journals/2016/brunacci_35164.pdf
Ending Page	65
Page Count	5
Starting Page	61
ISSN	09396411
DOI	10.1016/j.ejpb.2016.11.011
Journal	European Journal of Pharmaceutics and Biopharmaceutics
Volume Number	116
Language	English
Publisher	Elsevier BV
Publisher Date	2017-07-01
Access Restriction	Open
Subject Keyword	Journal: European Journal of Pharmaceutics and Biopharmaceutics Pharmacology and Pharmacy Submicron Particles
Content Type	Text
Resource Type	Article
Subject	Medicine Biotechnology Pharmaceutical Science

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