NDLI: T lymphocyte-mediated suppression of myeloma function in vitro. IV. Generation of effector suppressor cells specific for myeloma idiotypes.

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T lymphocyte-mediated suppression of myeloma function in vitro. IV. Generation of effector suppressor cells specific for myeloma idiotypes.

Content Provider	Scilit
Author	Abbas, A. K. Takaoki, M. Greene, M. I.
Copyright Year	1982
Description	Journal: The Journal of experimental medicine BALB/c mice immunized intravenously with syngeneic splenocytes, to which affinity-purified IgA produced by the MOPC 315 myeloma is covalently coupled, develop suppressor T cells (Ts1) that inhibit IgA secretion by MOPC 315 cells after 3-4 d of co-culture. Immunization with M315-coupled splenocytes subcutaneously, followed by administration of a soluble extract of Ts1 cells, leads to the generation of effector Ts that are also idiotype specific and inhibit myeloma function within 1 d. Moreover, effector Ts are Lyt-1-2+, whereas Ts1 are either Lyt-1+2+ or require Lyt-1+ and Lyt-2+ cells to mature into effector Ts in vitro. Such a protocol should be useful for analyzing the interactions that result in the maturation of Ts and in defining the mechanisms of action of Ts, whose effect can be measured on a homogeneous target population and that are specific for a well-characterized myeloma idiotype.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186645/pdf http://jem.rupress.org/content/155/4/1216.full.pdf
ISSN	00221295
DOI	10.1084/jem.155.4.1216
Journal	The Journal of experimental medicine
Issue Number	4
Volume Number	155
Language	English
Publisher	Rockefeller University Press
Publisher Date	1982-04-01
Access Restriction	Open
Subject Keyword	Journal: The Journal of experimental medicine Biochemical Research
Content Type	Text
Resource Type	Article
Subject	Physiology

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