NDLI: T lymphocyte-mediated suppression of myeloma function in vitro. III. Regulation of antibody production in hybrid myeloma cells by T lymphocytes.

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T lymphocyte-mediated suppression of myeloma function in vitro. III. Regulation of antibody production in hybrid myeloma cells by T lymphocytes.

Content Provider	Scilit
Author	Abbas, A. K. Burakoff, S. J. Gefter, M. L. Greene, M. I.
Copyright Year	1980
Description	To investigate the mechanisms by which T lymphocytes regulate myeloma function in vitro, the effects of regulatory T cells on antibody secretion by a hybrid myeloma cell line were examined. Suppressor T cells (Ts) specific for idiotypic determinants on M315 (IgA, lambda 2 anti-2,4-dinitrophenol and anti-2,4,6-trinitrophenol [TNP]) and MPC 11 (IgG2b, kappa) myeloma proteins inhibit antibody secretion by the appropriate parental myeloma cells. When cocultured with a hybrid cell line derived by fusion of MOPC 315 and MPC 11 myelomas, the idiotype-reactive Ts inhibit secretion of only the immunoglobulin (Ig) bearing the relevant idiotype. In contrast, syngeneic TNP-reactive cytolytic T lymphocytes (CTL) inhibit antibody secretion by TNP-binding MOPC 315 cells but not by MPC 11 cells in the presence of soluble TNP-keyhole limpet hemocyanin (KLH), and this inhibition probably represents a prelytic effect of the CTL. Such TNP-reactive CTL, in the presence of TNP-KLH, inhibit both IgA and IgG secretion by the MOPC 315-MPC 11 hybrid, which is consistent with a prelytic effect. Thus, myeloma hybrids are a useful tool for investigating the effector function of regulatory T cells. These results are discussed with reference to the mechanisms of action of regulatory T cells and their relevance to modulation of physiologic humoral immune responses.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2185970/pdf http://jem.rupress.org/content/152/4/969.full.pdf
Ending Page	978
Page Count	10
Starting Page	969
DOI	10.1084/jem.152.4.969
Journal	The Journal of experimental medicine
Issue Number	4
Volume Number	152
Language	English
Publisher	Rockefeller University Press
Publisher Date	1980-10-01
Access Restriction	Open
Subject Keyword	Hematology Antibody Function Lymphocytes Proteins Klh Ctl Regulate Hybrid Myeloma Prelytic Journal: The Journal of experimental medicine (Vol- 152, Issue- 4)
Content Type	Text

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