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Evaluation of cytotoxicity and genotoxicity of some Philippine medicinal plants
| Content Provider | Scilit |
|---|---|
| Author | Wudarski, Jakub Gevaert, Lieven Verschaeve, Luc Chichioco-Hernandez, Christine |
| Copyright Year | 2011 |
| Abstract | The genotoxicity and toxicity of ethnomedicinal Philippine plants, which include Cassia fistula, Derris elliptica, Ficus elastica, Gliciridia sepium, Michelia alba, Morus alba, Pogostemon cablin and Ricinus communis, were tested using the Vitotox assay. The plants are used traditionally to treat several disorders like diabetes, weakness, menorrhagia, headache, toothache and rheumatism. The dried leaves were homogenized for overnight soaking in methanol at room temperature. The resulting alcoholic extracts were filtered and concentrated in vacuo and tested for their genotoxicity and cytotoxicity using Vitotox®. Results showed that the medicinal plants that were tested are not genotoxic nor cytotoxic, except for R. communis and P. cablin, which showed toxicity at high doses (low dilutions) in the absence of S9. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113359/pdf http://www.phcog.com/article.asp?issn=0973-1296;year=2011;volume=7;issue=26;spage=171;epage=175;aulast=Chichioco-Hernandez;type=2 |
| File Format | XHTML |
| ISSN | 09731296 |
| e-ISSN | 09764062 |
| DOI | 10.4103/0973-1296.80683 |
| Journal | Pharmacognosy Magazine |
| Issue Number | 26 |
| Volume Number | 7 |
| Language | English |
| Publisher | Medknow |
| Access Restriction | Open |
| Subject Keyword | Integrative and Complementary Medicine Cytotoxicity Genotoxicity Medicinal Plants Plant Extracts Pogostemon Cablin Ricinus Communis Pharmacognosy Magazine, Volume 7, Issue 26 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Pharmaceutical Science |
