NDLI: Cytotoxic isoprenoids from Xanthium strumarium linn.

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Cytotoxic isoprenoids from Xanthium strumarium linn.

Content Provider	Scilit
Author	Alarif, Walied M. Bawakid, Nahed O. Elfaky, Mahmoud A. Ali, Aasim M. Ghandourah, Mohamed A. Amani, A. AlShehry Hajer, S. AlOrfi
Copyright Year	2020
Abstract	Background and Objective: Xanthium strumarium is a widespread medicinal plant species; particularly fruits and roots are known for improving memory, voice, and appetite as well as curing of poisonous bites of insects and epilepsy. Materials and Methods: The aerial parts of X. strumarium were extracted with a combination of organic solvents. The exhaustively dried organic extract was fractionated until obtaining pure individuals by employing the appropriate chromatographic techniques. The spectral information obtained from different nuclear magnetic resonance experiments, mass, infrared, and ultraviolet spectra were the keys to elucidate the chemical structures. Results: Nine compounds (1-9) were obtained: a germacrane sesquiterpene (1), five xanthatin-type sesquiterpenoids (5-9) with α-methylene-γ-lactone moiety, including the new one, methoxy xanthanol (9), a benzopyran derivative not previously found in nature 3,4-diepoxy-2,2-dimethyl-2H-1-benzopyran-6-carboxaldehyde (2), and coumarin (3), along with the C-28 steroid campesterol (4). Conclusion: Most of the compounds under the study showed an appreciated cytotoxic activity against HCT116 and HepG2 cancer cell lines.
Related Links	http://www.phcog.com/article.asp?issn=0973-1296;year=2020;volume=16;issue=70;spage=391;epage=395;aulast=Alorfi;type=2
File Format	XHTML
ISSN	09731296
e-ISSN	09764062
DOI	10.4103/pm.pm_585_19
Journal	Pharmacognosy Magazine
Issue Number	70
Volume Number	16
Language	English
Publisher	Medknow
Access Restriction	Open
Subject Keyword	Integrative and Complementary Medicine Asteraceae Cytotoxicity Medicinal Plants Spectroscopy Terpenoids Pharmacognosy Magazine, Volume 16, Issue 70
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Pharmaceutical Science

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