NDLI: Effects of Pogostemon cablin Blanco extract on hypoxia induced rabbit cardiomyocyte injury

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Effects of Pogostemon cablin Blanco extract on hypoxia induced rabbit cardiomyocyte injury

Content Provider	Scilit
Author	Cho, Su-In Lim, Chi-Yeon Kim, Bu-Yeo Lim, Se-Hyun
Copyright Year	2015
Abstract	Background: Pogostemonis Herba, the dried aerial part of Pogostemon cablin Blanco, is a well-known materia medica in Asia that is widely used for syndrome of gastrointestinal dysfunctions. Objective: This study was undertaken to examine whether Pogostemon cablin extract (PCe) might have any beneficial effect on hypoxia induced rabbit cardiomyocyte injury. Materials and Methods: Isolated cardiomyocytes were divided into three groups and the changes of cell viability in cardiomyocytes of hypoxic and hypoxia/reoxygenation group were determined. The effect of PCe on reactive oxygen species (ROS) generation, intracellular formation of ROS was also measured by monitoring the 2',7'- dichlorofluorescein fluorescence. Results: PCe effectively protected the cells against both the hypoxia and reoxygenation induced injury, and the protective effect of PCe is not mediated by interaction with adenosine triphosphate-sensitive K$ ^{+}$ channels. In the presence of PCe, production of ROS under chemical hypoxia was remarkably reduced which suggests that PCe might exert its effect as a ROS scavenger. Conclusion: The present study provides clear evidence for the beneficial effect of PCe on cardiomyocyte injury during hypoxia or reoxygenation following prolonged hypoxia.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378129/pdf http://www.phcog.com/article.asp?issn=0973-1296;year=2015;volume=11;issue=42;spage=311;epage=319;aulast=Lim;type=2
Ending Page	319
Page Count	9
Starting Page	311
File Format	XHTML
ISSN	09731296
e-ISSN	09764062
DOI	10.4103/0973-1296.153084
Journal	Pharmacognosy Magazine
Issue Number	42
Volume Number	11
Language	English
Publisher	Medknow
Publisher Date	2015-01-01
Access Restriction	Open
Subject Keyword	Integrative and Complementary Medicine Cardiomyocyte Hypoxia Pogostemon Cablin Pharmacognosy Magazine, Volume 11, Issue 42
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Pharmaceutical Science

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