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Incompatible crossmatch: First sign of a hemolytic transfusion reaction due to out-of-group platelet transfusion.
| Content Provider | Scilit |
|---|---|
| Author | Basu, Debapriya Basu, Sabita Roy, Joydeep Bhaumik, Jaydeep Reddy, Mahua Chandy, Mammen |
| Copyright Year | 2019 |
| Abstract | Platelet (PLT) transfusion is undertaken in a variety of clinical settings with thrombocytopenia, with or without bleeding. Since PLTs are most often stored in donor plasma, group-specific PLT transfusions are preferred to out-of-group transfusions. PLTs adsorb ABO antigens over their surface from the plasma. In major ABO-incompatible PLT transfusions, anti-A/B from the patient plasma react with the ABO antigens on transfused PLTs and can potentially cause adverse reactions or PLT refractoriness. Transfusion of PLTs with major ABO incompatibility, though effective in preventing clinical bleeding, is associated with reduced posttransfusion PLT count increments. In minor incompatible PLT transfusion transfused, anti-A/B can cause hemolytic transfusion reaction (HTR) which is not always related to a high titer of anti-A/B in the donor. Although attempts are made to practice ABO identical PLT transfusion, most centers practice out-of-group random donor platelets (RDPs) as well as single-donorplatelets (SDP) transfusion. The limited PLT shelf life does not always permit ABO identical PLT transfusion. At our center, ABO-specific PLT transfusions are practiced where possible, and in case of minor ABO-incompatible transfusions, antibody titers are not done. Here, we report a case of HTR due to out-of-group SDP transfusion, detected in the laboratory after an incompatible red blood cell (RBC) crossmatch. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580831/pdf http://www.ajts.org/article.asp?issn=0973-6247;year=2019;volume=13;issue=1;spage=57;epage=59;aulast=Basu;type=2 |
| Ending Page | 59 |
| Page Count | 3 |
| Starting Page | 57 |
| File Format | XHTML |
| ISSN | 09736247 |
| e-ISSN | 19983565 |
| DOI | 10.4103/ajts.AJTS_36_17 |
| Journal | Asian Journal of Transfusion Science |
| Issue Number | 1 |
| Volume Number | 13 |
| Language | English |
| Publisher | Medknow |
| Access Restriction | Open |
| Subject Keyword | Medical Laboratory Technology Hemolytic Transfusion Reaction Out-of-group Sdp Platelet Transfusion Asian Journal of Transfusion Science, Volume 13, Issue 1 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Hematology |
