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Antibody titers in Group O platelet donors
| Content Provider | Scilit |
|---|---|
| Author | Tendulkar, Anita Amar Jain, Puneet Ashok Velaye, Sanjay |
| Copyright Year | 2017 |
| Abstract | Background and Objectives: The occurrence of hemolysis due to transfusion of ABO plasma-incompatible platelets (PLTs) is challenging. There has been no consensus for critical antibody titers in the transfusion community. This study was conducted to understand the trends of anti-A and anti-B antibody titer levels in O group donors and to identify any specific patterns of distribution in relation to age and gender. Materials and Methods: A total of 1635 Group O PLT donors were randomly selected for this prospective study. Serial 2-fold doubling dilutions were prepared for each sample to calculate the titer of anti-A and anti-B in a standard 96 well micro-plate. Tube technique was used for comparison with the microplate method for 100 samples. Results: Out of 1635 donors, 1430 (87.46%) were males and 205 (12.54%) were females. The median titer for anti-A and anti-B was 128 with range from 4 to 2048. Spearman's correlation coefficient for microplate versus tube technique was estimated to be 0.803 (P < 0.01, two-tailed). 57.12% and 51.19% of all donors had titers ≥128 for anti-A and anti-B, respectively. The geometric mean of anti-A and anti-B was 155.7 and 137.28, respectively. The titers were significantly higher (P < 0.001) in female donors. An inverse relation between titer levels and age was seen. Conclusion: Microplate can be used to perform titers in resource-constrained settings. Screening for critical titers in O group donors is essential as they are more implicated in hemolytic transfusion reactions. In the absence of a global consensus on this topic, institutes may need to formulate their own guidelines on handling ABO plasma-incompatible PLT transfusions. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345276/pdf http://www.ajts.org/article.asp?issn=0973-6247;year=2017;volume=11;issue=1;spage=22;epage=27;aulast=Tendulkar;type=2 |
| Ending Page | 27 |
| Page Count | 6 |
| Starting Page | 22 |
| File Format | XHTML |
| ISSN | 09736247 |
| e-ISSN | 19983565 |
| DOI | 10.4103/0973-6247.200765 |
| Journal | Asian Journal of Transfusion Science |
| Issue Number | 1 |
| Volume Number | 11 |
| Language | English |
| Publisher | Medknow |
| Publisher Date | 2017-01-01 |
| Access Restriction | Open |
| Subject Keyword | Antibody Titers Hemolytic Transfusion Reaction O Group Platelet Donor Asian Journal of Transfusion Science, Volume 11, Issue 1 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Hematology |
